UniProt Accession

 CD276_HUMAN; Q5ZPR3; Q6P5Y4; Q6UXI2; Q8NBI8; Q8NC34; Q8NCB6; Q9BXR1 

Genbank Protein ID

 AF302102; AJ583695; AY358343; AK074849; AK074997; AK075549; BC062581 

Genbank Nucleotide ID

 AAK15438.1; CAE47548.1; AAQ88709.1; BAC11243.1; BAC11344.1; BAC11692.1; AAH62581.1 

Protein Name

 CD276 antigen 

Protein Synonyms/Alias

 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276 

Gene Name

 CD276 

Gene Synonyms/Alias

 B7H3; PSEC0249; UNQ309/PRO352 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
144	QVAAPYSKPSMTLEP	ubiquitination	[1]
526	PLKHSDSKEDDGQEI	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. 

Sequence Annotation

 DOMAIN 29 139 Ig-like V-type 1.
 DOMAIN 145 238 Ig-like C2-type 1.
 DOMAIN 243 357 Ig-like V-type 2.
 DOMAIN 363 456 Ig-like C2-type 2.
 MOD_RES 525 525 Phosphoserine.
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 189 189 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...).
 CARBOHYD 407 407 N-linked (GlcNAc...).
 CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
 DISULFID 50 122 By similarity.
 DISULFID 165 220 By similarity.
 DISULFID 268 340 By similarity.
 DISULFID 383 438 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; NAS:HGNC.
 GO:0016021; C:integral to membrane; NAS:HGNC.
 GO:0005102; F:receptor binding; NAS:HGNC.
 GO:0008283; P:cell proliferation; NAS:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0045077; P:negative regulation of interferon-gamma biosynthetic process; IEA:Compara.
 GO:0045085; P:negative regulation of interleukin-2 biosynthetic process; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IEA:Compara.
 GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IDA:HGNC.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IDA:HGNC.
 GO:0050776; P:regulation of immune response; NAS:HGNC.
 GO:0042110; P:T cell activation; IDA:UniProtKB. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS