UniProt Accession

 SIL1_HUMAN; Q9H173; D3DQC2; Q8N2L3 

Genbank Protein ID

 AJ299442; AF547994; AY358950; AK074624; AK075177; CH471062; CH471062; BC011568 

Genbank Nucleotide ID

 CAC17773.1; AAN84477.1; AAQ89309.1; BAC11096.1; BAC11452.1; EAW62120.1; EAW62121.1; AAH11568.1 

Protein Name

 Nucleotide exchange factor SIL1 

Protein Synonyms/Alias

 BiP-associated protein; BAP 

Gene Name

 SIL1 

Gene Synonyms/Alias

 UNQ545/PRO836 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	NPEKSSTKETERKET	ubiquitination	[1]
309	YAQRQFLKLGGLQVL	ubiquitination	[1, 2, 3]
323	LRTLVQEKGTEVLAV	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. 

Sequence Annotation

 REGION 1 256 Interaction with HSPA5 and localization
 CARBOHYD 193 193 N-linked (GlcNAc...).
 CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Disease mutation; Endoplasmic reticulum; Glycoprotein; Polymorphism; Protein transport; Reference proteome; Signal; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 461 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
 GO:0006886; P:intracellular protein transport; NAS:UniProtKB.
 GO:0006457; P:protein folding; NAS:UniProtKB. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 

Pfam

  

SMART

  

PROSITE

  

PRINTS