| Tag | Content |
|---|
| CPLM ID | CPLM-016131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone acetyltransferase KAT7 |
Protein Synonyms/Alias | Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2 |
Gene Name | Kat7 |
Gene Synonyms/Alias | Hbo1; Myst2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | KRNSGLSKEQKEKYM | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription (By similarity). |
Sequence Annotation | ZN_FING 367 389 C2HC-type.
REGION 483 489 Acetyl-CoA binding (By similarity).
ACT_SITE 433 433 By similarity.
ACT_SITE 475 475 Nucleophile (By similarity).
BINDING 478 478 Acetyl-CoA (By similarity).
BINDING 513 513 Acetyl-CoA (By similarity).
MOD_RES 51 51 Phosphoserine (By similarity).
MOD_RES 58 58 Phosphoserine; by PLK1 (By similarity).
MOD_RES 86 86 Phosphothreonine; by CDK1 (By
MOD_RES 89 89 Phosphothreonine; by CDK1 (By
MOD_RES 103 103 Phosphoserine (By similarity).
MOD_RES 125 125 Phosphoserine (By similarity).
MOD_RES 163 163 Phosphoserine (By similarity).
MOD_RES 165 165 Phosphoserine (By similarity).
MOD_RES 200 200 N6-acetyllysine (By similarity).
MOD_RES 433 433 N6-acetyllysine; by autocatalysis (By
MOD_RES 507 507 Phosphoserine (By similarity). |
Keyword | Acetylation; Acyltransferase; Alternative splicing; Chromatin regulator; Complete proteome; DNA replication; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 612 AA |
Protein Sequence | MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL SQSSQDSSPV 60
RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS SGSETEQAVD FSDRETKNTA 120
DHDESPPRTP TGNAPSSESD IDISSPNVSH DESIAKDMSL KDSGSDLSHR PKRRRFHESY 180
NFNMKCPTPG CNSLGHLTGK HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR 240
QDDNNRHATR HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE 300
NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT WYHSPYPEEY 360
ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY RKGSISVFEV DGKKNKIYCQ 420
NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA DNTGCHLIGY FSKEKNSFLN YNVSCILTMP 480
QYMRQGYGKM LIDFSYLLSK VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI 540
SIKEISQETA VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD 600
PSCLKWTPPK GT 612 |
Gene Ontology | GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB. GO:0004402; F:histone acetyltransferase activity; IEA:EC. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006260; P:DNA replication; ISS:UniProtKB. GO:0043966; P:histone H3 acetylation; ISS:UniProtKB. GO:0043983; P:histone H4-K12 acetylation; ISS:UniProtKB. GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB. GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |