CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042372
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myeloid differentiation primary response protein MyD88 
Protein Synonyms/Alias
  
Gene Name
 MYD88 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
107RLLELLTKLGRDDVLubiquitination[1, 2, 3, 4, 5, 6]
131DCQKYILKQQQEEAEubiquitination[4]
139QQQEEAEKPLQVAAVubiquitination[4]
202EQTNYRLKLCVSDRDubiquitination[6]
226IASELIEKRLARRPRubiquitination[4]
251SDDYLQSKECDFQTKubiquitination[4, 6]
258KECDFQTKFALSLSPubiquitination[4]
270LSPGAHQKRLIPIKYubiquitination[4, 6]
276QKRLIPIKYKAMKKEubiquitination[4]
282IKYKAMKKEFPSILRubiquitination[4]
302DYTNPCTKSWFWTRLubiquitination[3, 4]
311WFWTRLAKALSLP**ubiquitination[4, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 316 AA 
Protein Sequence
RPDRAEAPGP PAMAAGGPGA GSAAPVSSTS SLPLAALNMR VRRRLSLFLN VRTQVAADWT 60
ALAEEMDFEY LEIRQLETQA DPTGRLLDAW QGRPGASVGR LLELLTKLGR DDVLLELGPS 120
IEEDCQKYIL KQQQEEAEKP LQVAAVDSSV PRTAELAGIT TLDDPLGHMP ERFDAFICYC 180
PSDIQFVQEM IRQLEQTNYR LKLCVSDRDV LPGTCVWSIA SELIEKRLAR RPRGGCRRMV 240
VVVSDDYLQS KECDFQTKFA LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC 300
TKSWFWTRLA KALSLP 316 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0050830; P:defense response to Gram-positive bacterium; IEA:Compara.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Compara.
 GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Compara.
 GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0032740; P:positive regulation of interleukin-17 production; IEA:Compara.
 GO:0032747; P:positive regulation of interleukin-23 production; IEA:Compara.
 GO:0032755; P:positive regulation of interleukin-6 production; IEA:Compara.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0050671; P:positive regulation of lymphocyte proliferation; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0002238; P:response to molecule of fungal origin; IEA:Compara.
 GO:0032494; P:response to peptidoglycan; IEA:Compara.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0008063; P:Toll signaling pathway; IEA:Compara.
 GO:0045351; P:type I interferon biosynthetic process; IEA:Compara. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR017281; Myelin_different_resp_MyD88.
 IPR000157; TIR_dom. 
Pfam
 PF00531; Death
 PF01582; TIR 
SMART
 SM00005; DEATH
 SM00255; TIR 
PROSITE
 PS50017; DEATH_DOMAIN
 PS50104; TIR 
PRINTS