UniProt Accession

 GSTA5_RAT; P46418; Q6LD91 

Genbank Protein ID

 X78847; S72506; S82820 

Genbank Nucleotide ID

 CAA55404.1; AAP21065.1; AAB46796.1 

Protein Name

 Glutathione S-transferase alpha-5 

Protein Synonyms/Alias

 GST A5-5; Glutathione S-transferase Yc-2; GST Yc2 

Gene Name

 Gsta5 

Gene Synonyms/Alias

 Gstyc2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
138	RYFPAYEKVLKSHGQ	acetylation	[1]
141	PAYEKVLKSHGQDYL	acetylation	[1]
152	QDYLVGNKLSRADVS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide. 

Sequence Annotation

 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 207 GST C-terminal.
 REGION 54 55 Glutathione binding (By similarity).
 REGION 67 68 Glutathione binding (By similarity).
 BINDING 9 9 Glutathione (By similarity).
 BINDING 45 45 Glutathione (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005640; C:nuclear outer membrane; IDA:RGD.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0042493; P:response to drug; NAS:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0042178; P:xenobiotic catabolic process; IDA:RGD. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01266; GSTRNSFRASEA.