| Tag | Content |
|---|
| CPLM ID | CPLM-001136 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium-transporting ATPase type 2C member 2 |
Protein Synonyms/Alias | ATPase 2C2; Secretory pathway Ca(2+)-ATPase 2 |
Gene Name | ATP2C2 |
Gene Synonyms/Alias | KIAA0703; SPCA2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 634 | EEVDSVEKGELADRV | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity). |
Sequence Annotation | ACT_SITE 379 379 4-aspartylphosphate intermediate (By
METAL 332 332 Calcium 2; via carbonyl oxygen (By
METAL 333 333 Calcium 2; via carbonyl oxygen (By
METAL 335 335 Calcium 2; via carbonyl oxygen (By
METAL 337 337 Calcium 2 (By similarity).
METAL 674 674 Magnesium (By similarity).
METAL 678 678 Magnesium (By similarity).
METAL 768 768 Calcium 2 (By similarity).
METAL 772 772 Calcium 2 (By similarity).
MOD_RES 264 264 Phosphothreonine.
MOD_RES 267 267 Phosphoserine.
MOD_RES 268 268 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 946 AA |
Protein Sequence | MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT ALPPKEACKC 60
QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE PVWKKYLDQF KNPLILLLLG 120
SALVSVLTKE YEDAVSIATA VLVVVTVAFI QEYRSEKSLE ELTKMVPPEC NCLREGKLQH 180
LLARELVPGD VVSLSIGDRI PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT 240
TLSNIVFMGT LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL 300
FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG VLRMAKKRVI 360
VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL RAEVSGVGYD GQGTVCLLPS 420
KEVIKEFSNV SVGKLVEAGC VANNAVIRKN AVMGQPTEGA LMALAMKMDL SDIKNSYIRK 480
KEIPFSSEQK WMAVKCSLKT EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC 540
LQEEKRMGSL GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT 600
GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT SPKHKLKIIK 660
ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK EAANMILVDD DFSAIMNAVE 720
EGKGIFYNIK NFVRFQLSTS ISALSLITLS TVFNLPSPLN AMQILWINII MDGPPAQSLG 780
VEPVDKDAFR QPPRSVRDTI LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT 840
MTFTCFVFFD LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ 900
TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV 946 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005388; F:calcium-transporting ATPase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0034220; P:ion transmembrane transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |