CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Disks large homolog 3 
Protein Synonyms/Alias
 Neuroendocrine-DLG; Synapse-associated protein 102; SAP-102; SAP102; XLMR 
Gene Name
 DLG3 
Gene Synonyms/Alias
 KIAA1232 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
765QTYEQANKIYDKAMKacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. 
Sequence Annotation
 DOMAIN 130 217 PDZ 1.
 DOMAIN 226 311 PDZ 2.
 DOMAIN 379 465 PDZ 3.
 DOMAIN 503 568 SH3.
 DOMAIN 627 802 Guanylate kinase-like.
 MOD_RES 673 673 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 817 AA 
Protein Sequence
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PGGGNGASAG YGGYSSQTLP 60
SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG SGPSWWPECT CTNRDWYEQV 120
NGSDGMFKYE EIVLERGNSG LGFSIAGGID NPHVPDDPGI FITKIIPGGA AAMDGRLGVN 180
DCVLRVNEVD VSEVVHSRAV EALKEAGPVV RLVVRRRQPP PETIMEVNLL KGPKGLGFSI 240
AGGIGNQHIP GDNSIYITKI IEGGAAQKDG RLQIGDRLLA VNNTNLQDVR HEEAVASLKN 300
TSDMVYLKVA KPGSLHLNDM YAPPDYASTF TALADNHISH NSSLGYLGAV ESKVSYPAPP 360
QVPPTRYSPI PRHMLAEEDF TREPRKIILH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA 420
DLSGELRRGD RILSVNGVNL RNATHEQAAA ALKRAGQSVT IVAQYRPEEY SRFESKIHDL 480
REQMMNSSMS SGSGSLRTSE KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD 540
DEWWQARLVT PHGESEQIGV IPSKKRVEKK ERARLKTVKF HARTGMIESN RDFPGLSDDY 600
YGAKNLKGQE DAILSYEPVT RQEIHYARPV IILGPMKDRV NDDLISEFPH KFGSCVPHTT 660
RPRRDNEVDG QDYHFVVSRE QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR AVAERGKHCI 720
LDVSGNAIKR LQQAQLYPIA IFIKPKSIEA LMEMNRRQTY EQANKIYDKA MKLEQEFGEY 780
FTAIVQGDSL EEIYNKIKQI IEDQSGHYIW VPSPEKL 817 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0004385; F:guanylate kinase activity; NAS:UniProtKB.
 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; NAS:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF00018; SH3_1 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS