CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metal transporter CNNM1 
Protein Synonyms/Alias
 Ancient conserved domain-containing protein 1; mACDP1; Cyclin-M1; Cyclin-like protein 1; CLP-1 
Gene Name
 Cnnm1 
Gene Synonyms/Alias
 Acdp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
396STFYTREKLLETLRAubiquitination[1, 2]
526LEEFKKGKSHLAIVQubiquitination[1]
604SDSEIRVKISPQLLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Probable metal transporter (By similarity). 
Sequence Annotation
 DOMAIN 226 405 DUF21.
 DOMAIN 433 495 CBS 1.
 DOMAIN 502 568 CBS 2.  
Keyword
 CBS domain; Cell membrane; Complete proteome; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 951 AA 
Protein Sequence
MAAAAAAAAA LGVRLRDCCS RGAVLLLFFS LSPRPPAAAA WLLGLRPEDT AGGRVSLEGG 60
TLRAAEGTSF LLRVYFQPGP PVPAAPVPAP SLAPGENGTG DWAPRLVFIE EPPGAGGAAP 120
SAVPTRPPGP QRCREQSDWA SDVEVLGPLR PGGVAGSALV QVRVRELRKG EAERGGAGGG 180
GKLFSLCAWD GRAWHHHGAA GGFLLRVRPR LYGPGGDLLP PAWLRALGAL LLLALSALFS 240
GLRLSLLSLD PVELRVLRNS GSAAEQEQAR RVQAVRGRGT HLLCTLLLGQ AGANAALAGW 300
LYASLPPGVG DPGEDSGEAG VHFPWLPALV CTGAVFLGAE ICPYSVCSRH GLAIASHSVC 360
LTRLLMAAAF PVCYPLGRLL DWALRQEIST FYTREKLLET LRAADPYSDL VKEELNIIQG 420
ALELRTKVVE EVLTPLGDCF MLRSDAVLDF ATVSEILRSG YTRIPVYEGD QRHNIVDILF 480
VKDLAFVDPD DCTPLLTVTR FYNRPLHCVF NDTRLDTVLE EFKKGKSHLA IVQRVNNEGE 540
GDPFYEVMGI VTLEDIIEEI IKSEILDETD LYTDNRKKQR VPHRERRRHD FSLFKLSDSE 600
IRVKISPQLL LATHRFMATE VEPFKSLYLS EKILLRLLKH PNVIQELKFD ERNKKAPEHY 660
LYQRNRPVDY FVLLLQGKVE VEVGKEGLRF ENGAFTYYGV PAIMTSACSD NDVRKVGSLA 720
GSSVFLNRSP SRCSGLNRSE SPNRERSDFG GSNTQLYSSS NNLYTPDYSV HILSDVQFVK 780
ITRQQYQNAL TACHMDSSPQ SPDMEAFTDG DSTKAPTTRG TPQTPKDDPV LTLLSNRTSL 840
PCSRSDGLRS PGEVVYLRME EMAFPQEEMP NFEEHRSQQV SLSPVAVPTT AASDPECCNI 900
HLDPEASPCS SDSEENMGKK LLRTLSGRKR KKSADGERAS EENSNLTPLI T 951 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR000644; Cysta_beta_synth_core.
 IPR002550; DUF21. 
Pfam
 PF00571; CBS
 PF01595; DUF21 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS 
PRINTS