CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017481
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 13C 
Protein Synonyms/Alias
  
Gene Name
 ANKRD13C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173HNAPVKVKNAQGWSPubiquitination[1, 2]
271LIDFTDMKCQRGDLSubiquitination[2]
395AIMESLSKGGNIMEQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. 
Sequence Annotation
 REPEAT 111 142 ANK 1.
 REPEAT 143 172 ANK 2.
 REPEAT 176 205 ANK 3.  
Keyword
 Alternative splicing; ANK repeat; Chaperone; Complete proteome; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC HKIFSNHHHR 60
LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP VAVVADGGSC PAHYPVHECV 120
FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL AVMLGNKECA HLLLAHNAPV KVKNAQGWSP 180
LAEAISYGDR QMITALLRKL KQQSRESVEE KRPRLLKALK ELGDFYLELH WDFQSWVPLL 240
SRILPSDACK IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV 300
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK TERVGNFLAD 360
FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGNIM EQNFEPIRRQ SLTPPPQNTI 420
TWEEYISAEN GKAPHLGREL VCKESKKTFK ATIAMSQEFP LGIELLLNVL EVVAPFKHFN 480
KLREFVQMKL PPGFPVKLDI PVFPTITATV TFQEFRYDEF DGSIFTIPDD YKEDPSRFPD 540
L 541 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0006621; P:protein retention in ER lumen; IMP:BHF-UCL.
 GO:2000209; P:regulation of anoikis; IDA:BHF-UCL.
 GO:0010869; P:regulation of receptor biosynthetic process; IDA:BHF-UCL. 
Interpro
 IPR021832; ANKRD13.
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2
 PF11904; GPCR_chapero_1 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS