UniProt Accession

 CEBPD_HUMAN; P49716; Q14937; Q2M2X9 

Genbank Protein ID

 M83667; S63168; CH471068; BC105109 

Genbank Nucleotide ID

 AAA59927.1; AAB27293.1; EAW86679.1; AAI05110.1 

Protein Name

 CCAAT/enhancer-binding protein delta 

Protein Synonyms/Alias

 C/EBP delta; Nuclear factor NF-IL6-beta; NF-IL6-beta 

Gene Name

 CEBPD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	PAAPRLLKREPDWGD	sumoylation	[1, 2]

Reference

 [1] Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
 Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC.
 J Biol Chem. 2002 Oct 11;277(41):38037-44. [PMID: 12161447]
 [2] Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.
 Wang JM, Ko CY, Chen LC, Wang WL, Chang WC.
 Nucleic Acids Res. 2006;34(1):217-31. [PMID: 16397300] 

Functional Description

 C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages. 

Sequence Annotation

 DOMAIN 191 254 bZIP.
 REGION 195 222 Basic motif (By similarity).
 REGION 226 254 Leucine-zipper (By similarity).
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS