UniProt Accession

 NACA2_HUMAN; Q9H009; Q2VIR9 

Genbank Protein ID

 AJ278883; BC062710; DQ120612 

Genbank Nucleotide ID

 CAC06614.1; AAH62710.1; ABB92399.1 

Protein Name

 Nascent polypeptide-associated complex subunit alpha-2 

Protein Synonyms/Alias

 Alpha-NAC-like; Hom s 2.01; Nascent polypeptide-associated complex subunit alpha-like; NAC-alpha-like 

Gene Name

 NACA2 

Gene Synonyms/Alias

 NACAL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	NILFVITKLDVYKSP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). 

Sequence Annotation

 DOMAIN 70 135 NAC-A/B.
 DOMAIN 176 213 UBA.
 MOD_RES 214 214 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR016641; EGD2/NACA.
 IPR002715; Nas_poly-pep-assoc_cplx_dom. 

Pfam

 PF01849; NAC 

SMART

  

PROSITE

 PS51151; NAC_AB
 PS50030; UBA 

PRINTS