UniProt Accession

 ESF2_YEAST; P53743; D6W1M9 

Genbank Protein ID

 Z71669; BK006947 

Genbank Nucleotide ID

 CAA96335.1; DAA10595.1 

Protein Name

 Pre-rRNA-processing protein ESF2 

Protein Synonyms/Alias

 18S rRNA factor 2 

Gene Name

 ESF2 

Gene Synonyms/Alias

 ABT1; YNR054C; N3491 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
34	TKKKISSKDDIFSKK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2. Stimulates DBP8 RNA helicase ATPase activity. 

Sequence Annotation

 DOMAIN 114 204 RRM.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 14 14 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0001671; F:ATPase activator activity; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0034462; P:small-subunit processome assembly; IMP:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait. 

Pfam

  

SMART

  

PROSITE

 PS50102; RRM 

PRINTS