Tag | Content |
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CPLM ID | CPLM-010663 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-mercaptopyruvate sulfurtransferase |
Protein Synonyms/Alias | MST |
Gene Name | Mpst |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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21 | QWVAEALKSPRASQP | acetylation | [1] | 30 | PRASQPLKLLDASWY | acetylation | [1] | 40 | DASWYLPKLGRDARR | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. |
Sequence Annotation | DOMAIN 25 144 Rhodanese 1. DOMAIN 174 288 Rhodanese 2. REGION 145 160 Hinge. ACT_SITE 248 248 Cysteine persulfide intermediate. BINDING 188 188 Substrate (By similarity). DISULFID 155 155 Interchain (with C-155 or C-264); redox- DISULFID 264 264 Interchain (with C-155 or C-264); redox- |
Keyword | Cell junction; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Mitochondrion; Redox-active center; Reference proteome; Repeat; Synapse; Synaptosome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 297 AA |
Protein Sequence | MAAPQLFRAL VSAQWVAEAL KSPRASQPLK LLDASWYLPK LGRDARREFE ERHIPGAAFF 60 DIDRCSDHTS PYDHMLPSAT HFADYAGSLG VSAATHVVIY DGSDQGLYSA PRVWWMFRAF 120 GHHSVSLLDG GFRYWLSQNL PISSGKSPSE PAEFCAQLDP SFIKTHEDIL ENLDARRFQV 180 VDARAAGRFQ GTQPEPRDGI EPGHIPGSVN IPFTEFLTSE GLEKSPEEIQ RLFQEKKVDL 240 SKPLVATCGS GVTACHVVLG AFLCGKPDVP VYDGSWVEWY MRAQPEHVIS QGRGKTL 297 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IEA:Compara. GO:0005739; C:mitochondrion; IDA:UniProtKB. GO:0043005; C:neuron projection; ISS:UniProtKB. GO:0045202; C:synapse; IEA:UniProtKB-KW. GO:0016784; F:3-mercaptopyruvate sulfurtransferase activity; IEA:EC. GO:0004792; F:thiosulfate sulfurtransferase activity; IEA:InterPro. GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |