UniProt Accession

 F6QR24_HUMAN; F6QR24 

Genbank Protein ID

 AL138724; AL138824; AL157776 

Genbank Nucleotide ID

  

Protein Name

 Nuclear pore complex protein Nup153 

Protein Synonyms/Alias

  

Gene Name

 NUP153 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	VGGGGGGKIRTRRCH	ubiquitination	[1, 2, 3]
27	RCHQGPIKPYQQGRQ	acetylation	[3]
48	SRVTESVKNIVPGWL	ubiquitination	[1, 2, 3, 4, 5]
170	FSLVKEIKDSTSQHD	ubiquitination	[2]
194	FSSRASDKDITVSKN	acetylation	[3]
200	DKDITVSKNTSLPPL	ubiquitination	[2, 5, 6]
227	QHTATSSKKPAFNLS	ubiquitination	[5]
250	LGNSSILKTSQLGDS	ubiquitination	[7]
263	DSPFYPGKTTYGGAA	ubiquitination	[2, 3, 4, 5, 6]
294	VRRQMKAKQLSAQSY	ubiquitination	[3, 5]
317	RILQSLEKMSSPLAD	ubiquitination	[6]
353	DITDFQAKREKVDSQ	ubiquitination	[2]
384	TNRSVYFKPSLTPSG	acetylation	[3, 8]
384	TNRSVYFKPSLTPSG	ubiquitination	[2, 4]
644	GSVLDILKSPGFASP	ubiquitination	[2, 3, 6]
733	TGIETPNKSGKTTLS	ubiquitination	[5]
896	ELCLVQNKADSTKCL	ubiquitination	[7]
917	PGTKSGFKGFDTSSS	ubiquitination	[2, 5, 6]
956	LTSTGNFKFGDQGGF	ubiquitination	[5, 6]
964	FGDQGGFKIGVSSDS	ubiquitination	[5]
985	SEGFKFSKPIGDFKF	acetylation	[8]
985	SEGFKFSKPIGDFKF	ubiquitination	[3, 4, 6]
991	SKPIGDFKFGVSSES	ubiquitination	[4]
999	FGVSSESKPEEVKKD	ubiquitination	[6]
1004	ESKPEEVKKDSKNDN	ubiquitination	[6]
1013	DSKNDNFKFGLSSGL	ubiquitination	[6]
1041	SNLGQEEKKEELPKS	ubiquitination	[5, 6]
1087	NLGTIETKSASVAPF	ubiquitination	[3, 7]
1097	SVAPFTCKTSEAKKE	ubiquitination	[2]
1102	TCKTSEAKKEEMPAT	ubiquitination	[5]
1110	KEEMPATKGGFSFGN	ubiquitination	[5]
1137	VLGRTEEKQQEPVTS	ubiquitination	[6]
1151	STSLVFGKKADNEEP	ubiquitination	[4, 5, 6]
1179	TKDENSSKSTFSFSM	ubiquitination	[4, 5, 6]
1188	TFSFSMTKPSEKESE	ubiquitination	[5, 6]
1192	SMTKPSEKESEQPAK	ubiquitination	[5, 6]
1199	KESEQPAKATFAFGA	ubiquitination	[5]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1506 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR026054; Nucleoporin.
 IPR013913; Nucleoporin_Nup153.
 IPR018892; Retro-transposon_transp_CS.
 IPR001876; Znf_RanBP2. 

Pfam

 PF08604; Nup153
 PF10599; Nup_retrotrp_bd
 PF00641; zf-RanBP 

SMART

 SM00547; ZnF_RBZ 

PROSITE

 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 

PRINTS