CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013232
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homocysteine S-methyltransferase 
Protein Synonyms/Alias
 S-methylmethionine:homocysteine methyltransferase 
Gene Name
 mmuM 
Gene Synonyms/Alias
 yagD; b0261; JW0253 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
307PADIAALKARS****acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine. 
Sequence Annotation
 DOMAIN 1 310 Hcy-binding.
 METAL 229 229 Zinc (Potential).
 METAL 295 295 Zinc (Potential).
 METAL 296 296 Zinc (Potential).  
Keyword
 Amino-acid biosynthesis; Complete proteome; Metal-binding; Methionine biosynthesis; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 310 AA 
Protein Sequence
MSQNNPLRAL LDKQDILLLD GAMATELEAR GCNLADSLWS AKVLVENPEL IREVHLDYYR 60
AGAQCAITAS YQATPAGFAA RGLDEAQSKA LIGKSVELAR KAREAYLAEN PQAGTLLVAG 120
SVGPYGAYLA DGSEYRGDYH CSVEAFQAFH RPRVEALLDA GADLLACETL PNFSEIEALA 180
ELLTAYPRAR AWFSFTLRDS EHLSDGTPLR DVVALLAGYP QVVALGINCI ALENTTAALQ 240
HLHGLTVLPL VVYPNSGEHY DAVSKTWHHH GEHCAQLADY LPQWQAAGAR LIGGCCRTTP 300
ADIAALKARS 310 
Gene Ontology
 GO:0008898; F:homocysteine S-methyltransferase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR003726; S_MeTrfase. 
Pfam
 PF02574; S-methyl_trans 
SMART
  
PROSITE
 PS50970; HCY 
PRINTS