| Tag | Content |
|---|
| CPLM ID | CPLM-022430 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Molybdenum cofactor biosynthesis protein 1 |
Protein Synonyms/Alias | Cell migration-inducing gene 11 protein; Molybdenum cofactor synthesis-step 1 protein A-B; Cyclic pyranopterin monophosphate synthase; Molybdenum cofactor biosynthesis protein A; Cyclic pyranopterin monophosphate synthase accessory protein; Molybdenum cofactor biosynthesis protein C |
Gene Name | MOCS1 |
Gene Synonyms/Alias | MIG11 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 198 | VRRKGFHKVMEGIHK | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). |
Sequence Annotation | REGION 1 383 Molybdenum cofactor biosynthesis protein
REGION 317 319 GTP binding (By similarity).
REGION 414 636 Molybdenum cofactor biosynthesis protein
ACT_SITE 606 606 For molybdenum cofactor biosynthesis
METAL 80 80 Iron-sulfur 1 (4Fe-4S-S-AdoMet)
METAL 84 84 Iron-sulfur 1 (4Fe-4S-S-AdoMet)
METAL 87 87 Iron-sulfur 1 (4Fe-4S-S-AdoMet)
METAL 312 312 Iron-sulfur 2 (4Fe-4S-substrate)
METAL 315 315 Iron-sulfur 2 (4Fe-4S-substrate)
METAL 329 329 Iron-sulfur 2 (4Fe-4S-substrate)
BINDING 73 73 GTP (By similarity).
BINDING 86 86 S-adenosyl-L-methionine (By similarity).
BINDING 123 123 GTP (By similarity).
BINDING 127 127 S-adenosyl-L-methionine; via carbonyl
BINDING 154 154 GTP (By similarity).
BINDING 178 178 S-adenosyl-L-methionine (By similarity).
BINDING 215 215 GTP (By similarity).
BINDING 249 249 S-adenosyl-L-methionine; via amide
MOD_RES 198 198 N6-acetyllysine. |
Keyword | 4Fe-4S; Acetylation; Alternative splicing; Complete proteome; Disease mutation; GTP-binding; Iron; Iron-sulfur; Lyase; Metal-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding; Polymorphism; Reference proteome; S-adenosyl-L-methionine. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 636 AA |
Protein Sequence | MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL REHAAPFSAF 60
LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN LLTTEEILTL ARLFVKEGID 120
KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT IGVTTNGINL ARLLPQLQKA GLSAINISLD 180
TLVPAKFEFI VRRKGFHKVM EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP 240
LDVRFIEYMP FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ 300
ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE LLRIIGAAVG 360
RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF SWDPLHVQGL RPRMSFSSQV 420
ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT SRADSDANSK CLSPGSWASA APSGPQLTSE 480
QLTHVDSEGR AAMVDVGRKP DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG 540
VQAAKVTSQL IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA 600
ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA 636 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0019008; C:molybdopterin synthase complex; IEA:InterPro. GO:0005634; C:nucleus; NAS:UniProtKB. GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0016829; F:lyase activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IDA:UniProtKB. GO:0006767; P:water-soluble vitamin metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |