CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014222
UniProt Accession
Genbank Protein ID
 U41899 
Genbank Nucleotide ID
Protein Name
 Brain-specific angiogenesis inhibitor 1-associated protein 2 
Protein Synonyms/Alias
 BAI-associated protein 2; BAI1-associated protein 2; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53; Insulin receptor tyrosine kinase 53 kDa substrate; p58/p53 
Gene Name
 BAIAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
NCBI Taxa ID
 10029 
Lysine Modification
Position
Peptide
Type
References
171YIDAISNKQGELENYubiquitination[1]
351VRKSVTPKNSYATTEubiquitination[1]
360SYATTENKTLPRSSSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity). 
Sequence Annotation
 DOMAIN 1 250 IMD.
 DOMAIN 375 438 SH3.
 MOD_RES 324 324 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphothreonine (By similarity).
 MOD_RES 347 347 Phosphoserine (By similarity).
 MOD_RES 367 367 Phosphoserine (By similarity).
 MOD_RES 453 453 Phosphoserine (By similarity).
 MOD_RES 454 454 Phosphoserine (By similarity).
 MOD_RES 455 455 Phosphoserine (By similarity).  
Keyword
 Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK GYFDALVKMG 60
ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL 120
KKYQAEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS 180
DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPVWQQAC ADPNKIPDRA 240
VQLMQQIASS NGSILPSTLS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM 300
NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP KNSYATTENK 360
TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE 420
KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLAVPPP DYGTSSRAFP 480
TQTAGTFKQR PYSVAVPAFS QGLDDYGARS VSSADVEVAR F 521 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0070064; F:proline-rich region binding; ISS:UniProtKB.
 GO:0051764; P:actin crosslink formation; ISS:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
 GO:0046847; P:filopodium assembly; IEA:InterPro.
 GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.
 GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
 GO:0009617; P:response to bacterium; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR013606; IRSp53/MIM_homology_IMD.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF08397; IMD
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS51338; IMD
 PS50002; SH3 
PRINTS