UniProt Accession

 MARE3_RAT; Q5XIT1 

Genbank Protein ID

 BC083589 

Genbank Nucleotide ID

 AAH83589.1 

Protein Name

 Microtubule-associated protein RP/EB family member 3 

Protein Synonyms/Alias

 EB1 protein family member 3; EBF3; End-binding protein 3; EB3; RP3 

Gene Name

 Mapre3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
76	HEYIHNFKVLQAAFK	acetylation	[1]
83	KVLQAAFKKMGVDKI	acetylation	[1]
113	EFIQWFKKFFDANYD	acetylation	[1]
113	EFIQWFKKFFDANYD	ubiquitination	[2]
122	FDANYDGKDYNPLLA	acetylation	[1]
229	ERDFYFSKLRDIELI	ubiquitination	[3]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). 

Sequence Annotation

 DOMAIN 14 116 CH.
 DOMAIN 194 264 EB1 C-terminal.
 REGION 217 281 DCTN1-binding (By similarity).
 REGION 217 260 APC-binding (By similarity).
 MOD_RES 161 161 Phosphothreonine (By similarity).  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005881; C:cytoplasmic microtubule; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR001715; CH-domain.
 IPR004953; EB1_C.
 IPR027328; MAPRE. 

Pfam

 PF00307; CH
 PF03271; EB1 

SMART

  

PROSITE

 PS50021; CH
 PS51230; EB1_C 

PRINTS