CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039912
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein angel homolog 2 
Protein Synonyms/Alias
  
Gene Name
 ANGEL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26KTKILGDKNVDPKCEacetylation[1]
252YEGLPIGKVSGQEQSubiquitination[1, 2, 3]
293QQVPKVEKTDSDLTQubiquitination[1, 3]
304DLTQTQLKQTEVLVTubiquitination[2, 4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MEGVIKRNWE YICSHDKEKT KILGDKNVDP KCEDSENKFD FSVMSYNILS QDLLEDNSHL 60
YRHCRRPVLH WSFRFPNILK EIKHFDADVL CLQEVQEDHY GAEIRPSLES LGYHCEYKMR 120
TGRKPDGCAI CFKHSKFSLL SVNPVEFFRP DISLLDRDNV GLVLLLQPKI PYAACPAICV 180
ANTHLLYNPR RGDIKLTQLA MLLAEISSVA HQKDGSFCPI VMCGDFNSVP GSPLYSFIKE 240
GKLNYEGLPI GKVSGQEQSS RGQRILSIPI WPPNLGISQN CVYEVQQVPK VEKTDSDLTQ 300
TQLKQTEVLV TAEKLSSNLQ HHFSLSSVYS HYFPDTGIPE VTTCHSRSAI TVDYIFYSAE 360
KEDVAGHPGA EVALVGGLKL LARLSLLTEQ DLWTVNGLPN ENNSSDHLPL LAKFRLEL 418 
Gene Ontology
  
Interpro
 IPR005135; Endo/exonuclease/phosphatase. 
Pfam
 PF03372; Exo_endo_phos 
SMART
  
PROSITE
  
PRINTS