CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036410
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TBC1 domain family member 4 
Protein Synonyms/Alias
  
Gene Name
 Tbc1d4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
484GLYPPRAKLVIQRHLacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1306 AA 
Protein Sequence
MESPSCIQDE PFPHPLEPEP SAPAQPGATK PGDKRFRLWY VGGSCLDRRT TLPMLPWLMA 60
EIRRRSQKPD AGGCGAPAAR EVILVLSAPF LRCVPAPGAG VGGGAGSGAV QPNTGVFIFE 120
HKAQHISRFI HNSHDLTYFA YLIKAQPDDP ESQMACHVFR ATDPNQVPDV ISSIRQLSKA 180
AMKEDSKPSK DNEDAFYNSQ KFEVLYCGRV IVTHKKAPSS LIDDCKDKFS LHEQQRLKLQ 240
GERGGDPGDE MGVLEVESPV SPDDSLPEKA DGTVNSPRAL PSLASLPALA SQPALASSRV 300
CFPERILEDC GFDEQQEFRS RCSSVTGVMQ KKVHENNQKT QPRRRHASAP SHVQPSDSEK 360
NRTMLFQVGR FEINLISPDT KSVVLEKNFK DISSCSQGIK HVDHFGFICR ESPEPGLSQY 420
ICYVFQCANE SLVDEVMLTL KQAFSTAAAL QSAKTQIKLC ETCPMHSLHK LCERIEGLYP 480
PRAKLVIQRH LSSLTDNEQA DIFERVQKMK PISDQEENEL VILHLRQLCE AKQRTHVHIG 540
EGPAIISNST IPENVTSGGR FKLDVLKNKA KRSLTSSLEN IFSRGANRMR GRLGSMDSFE 600
RANSLASEKD FSPGDSPPGT PPASPLSSAW HAFPEEDSDS PQFRRRAHTF SHPPSSSRRK 660
LNLQDGKAHG LRSPLLRQSS SEQCSIVPSA RRMYKESNSS CSLPSLHTSF SAPSFTAPSF 720
LKSFYQNSGR LSPQYENEIR QDTASESSDG EGRKRTSSTC SNESLNAGGT PVTPRRVSWR 780
QRIFLRVASP VNKSPSAMQQ QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE 840
KKKSKELKSL WKKAIHQQIL LLRMEKENQK LEARRDELQS RKVKLDYEEV GTCQKEILIA 900
WDKKLLNCRT KIRCDMEDIH TSLKEGVPKS RRGEIWQFLA LQYRLRHRLP NKHQPPDTSY 960
KELLKQLTAQ QHAILVDLGR TFPTHPYFSV QLGAGQLSLF NLLKAYSLLD KEVGYCQGIS 1020
FVAGVLLLHM SEEQAFEMLK FLMYDLGFRK QYRPDMMSLQ IQMYQLSRLL HDYHRELYNH 1080
LEENEISPSL YAAPWFLTLF ASQFPLGFVA RVFDIIFLQG TEVIFKVALS LLSSQEALIM 1140
ECENFENIVE FLKSTLPDMN TTEMEKIITQ VFEMDISKQL HAYEVEYHVL QDELLESSYA 1200
CEDNESLEKL ERANNQLKRQ NMDLLEKLQV AHAKIQALES NLETLLTRET KMKALIRTLE 1260
QDKMAYQKTV EQIRKLLPAD ALANCELLLK DLTHPTNDKA KAGNKP 1306 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR021785; DUF3350.
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF11830; DUF3350
 PF00640; PID
 PF00566; RabGAP-TBC 
SMART
 SM00462; PTB
 SM00164; TBC 
PROSITE
 PS01179; PID
 PS50086; TBC_RABGAP 
PRINTS