CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium channel subunit beta-3 
Protein Synonyms/Alias
  
Gene Name
 Scn3b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
186YCYRKVSKAEEAAQEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. 
Sequence Annotation
 DOMAIN 25 138 Ig-like C2-type.
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 113 113 N-linked (GlcNAc...) (Potential).
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 DISULFID 26 48 Potential.
 DISULFID 45 120 Potential.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel; Ion transport; Membrane; Reference proteome; Signal; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV 60
EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC 120
NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLFIEMIYC 180
YRKVSKAEEA AQENASDYLA IPSENKENSV VPVEE 215 
Gene Ontology
 GO:0016021; C:integral to membrane; IDA:RGD.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0001518; C:voltage-gated sodium channel complex; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0086006; F:voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0007399; P:nervous system development; IEP:RGD.
 GO:0010460; P:positive regulation of heart rate; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0086014; P:regulation of atrial cardiac muscle cell action potential; IEA:Compara.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0086070; P:SA node cell to atrial cardiac muscle cell communication; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEP:RGD.
 GO:0006814; P:sodium ion transport; IDA:RGD. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR027098; Na_channel_b1/b3.
 IPR027096; Na_channel_b3. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS