CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039060
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Dnah2 
Protein Synonyms/Alias
  
Gene Name
 Dnah2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1578NCRMALKKFLNKRDKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4371 AA 
Protein Sequence
ITTLNLILSC SRAGSCSGGL KPIFLSRAML TGLADSTWTA EHDAVLEHFA QDPSVPVLTI 60
FVDPVFGLKL ELGMPVQTQN QIVYFIRQAP VPITPENFEE TVQYGTVRGA YIPALLRLLS 120
GVYVPQIFMN KSWPESIRNH FVSHLHRFLA SLTDTRYKLE GHTVLYIPAE AITMDPAVVI 180
KDKELVQRLE TSMIHWTRQI KEVLSAQESV DTGENLGPLE EIEFWNNRCM DLSGISKQLV 240
KQGVKHIESI LLLAKSSYLA PFRKLAQQIQ DGSRQAQSNL TFLSILREPY QELAFMKPKD 300
ISDKLPKLIS LIRIIWVNSP HYNTRERLTG LFRKVCDCQY HFARWLDGTQ GPLPCFFGAQ 360
GPQITRNLLE IEDIFHKNLQ TLRAVRGGIL DVKNTSWHED YNKFRAGIKD LEVMTQNLIT 420
SAFELVRDVE HGVLLLDTFH RLANREAIMR TYEKKAVDLY MLFNSELALV NRELNKKWPY 480
LEPYMAQYSG QAHWVRILRR RIDRVMNCLS GAHFLPHIGT GEETVHTYQQ MVQAIDELVR 540
KTFQEWTATL DKDCIRRLDM PLLRISQEKA GMLDVNFDKT LLILFVEIDY WERLLFETPH 600
YVMNVADRAE DLRILRENLL LVARDYNRII AMLSPDEQAL FKERIRFLDK KIHPGLKKLN 660
WALKGASAFF ITECRIHASK VQMIVNDFKA STLTIGWKAQ EMSELLLVHI TGKQVYRDLE 720
FEEAQREHRM AVQQKLVNLH QDVINILTNS FEVFKNDGPE IQQQWLLYTI RLDHMMEDAL 780
RLNVKWSLLE LSKAINGDGK TSPNPLFRVL VILQSDVQGG GAQVEFSPTL QTLASVVNDI 840
GSHLFSTISV FRHLPDILTK RKMTREPIHV VVERDEDIRK IQAQISSGMT NNASLLQNYL 900
KTWDMYREIW EINKDSFIRR YQRLNPPVSS FDADIARYTE VANNVQKEET VLNIQFVMLD 960
CSHLKFSLVQ HCNEWQNKFT TLLKEMAAGR LMDLHTYLKD NAEKISRPPQ TLEELGVSLQ 1020
LMDTLQHDLP NLETQIPPIH EQFTILEKYE VPVPDTVLEM LESLNGEWLT FQQILLDSEQ 1080
MLKKHKEKFK TGLIHAADDF KKKAHNLLED FELKGPFTSN VGHTAALDQI AQVRAMLMAM 1140
REEESNLRSN LGIFKIEQPI SKDLQNLEKE LDALQQVWEI TRDWEESWNQ WKTGCFLTLQ 1200
TEAMESMAHG LFRRLTRLAK EYKDRNWEVI ETTRAKIEQF KRTMPLISDL RNPALRERHW 1260
DQVKEEIQRE FDQESESFTL EQIVKLGMDQ HVEKIAEISA SATKELAIEV GLQNIAKTWD 1320
STQLDIVPYK DKGHHRLRGT EEVFQALEDN QVALSTMKAS RFVKAFEKDV DHWERCLSLI 1380
LEVIEMVLTV QRQWMYLENI FLGEDIRKQL PNESALFDQV NNNWKGIMDR MNKDNNALRS 1440
THYPGLLETL IEMNTILEDI QKSLDMYLET KRHMFPRFYF LSNDDLLEIL GQSRNPEAVQ 1500
PHLKKCFDNI KLLKIQKVGG SSSKWEAVGM FSGDGEYIDF LHPVLLEGAV ESWLGDVERA 1560
MRMTLRDLLR NCRMALKKFL NKRDKWVKDW AGQMVITASQ IQWTADVTKC LMTAKERSDK 1620
KILKVMKKKQ VSILNKYSEA IRGNLTKIMR LKIVALVTIE IHARDVLEKL YKGGLMDVNA 1680
FDWLSQLRFY WEKDVDDCII RQTNTQFQYG YEYLGNSGRL VITPLTDRCY MTLTTALHLH 1740
RGGSPKGPAG TGKTETVKDL GKALGTYVIV VNCSEGLDYK SMGRMYSGLA QTGAWGCFDE 1800
FNRINIEVLS VVAQQILSIL SALTANLTRF YFEGFEINLV WSCGIFITMN PGYAGRTELP 1860
ENLKSMFRPI AMVVPDSTLI AEIILFGEGF GNCKILAKKV YTLYSLAVQQ LSRQDHYDFG 1920
LRALTSLLRY AGKKRRLQPD LTDEEVLLLS MRDMNIAKLT SVDVPLFNAI VQDLFPNIEL 1980
PVIDYGKLRD TIEQEIREMG LQITPFTLTK VLQLYETKNS RHSTMIVGGT GSSKTTSWRI 2040
LQASLTSLCR AGEPNFNIVK EFPLNPKALS LGELYGEYDL NTNEWTDGIL SSVMRAACAD 2100
EKPDEKWILF DGPVDTLWIE SMNSVMDDNK VLTLINGERI AMPEQVSLLF EVENLAVASP 2160
ATVSRCGMVY TDYVDLGWTP YVQSWLEKRP KAEIEPLQRM FEKFINKILT FKKDNCNELV 2220
PVTEYSGIIS LCKLYTVLAT PENGVNPADT ENHAFMVEMT FVFSMIWSVC ASVDEDGRKK 2280
IDSYLREIEG SFPNKDTVYE YYVNPKMRTW SSFEEQLPKS WRYPPNAPFY KIMVPTVDTV 2340
RYNYLVSTLV ANQNPVLLVG PVGTGKTSIA QSVLQSLPSS QWSVLVVNMS AQTTSNNVQS 2400
IIESRVEKRT KGVYVPFGGK SMITFMDDLN MPAKDMFGSQ PPLELIRLWI DYGFWYDRVK 2460
QTIKHIRDMF LMAAMGPPGG GRTVISPRLQ SRFNIINMTF PTESQIIRIF GTMINQKLQD 2520
FEEEVKPIGN VVTEATLDVY NTVVQRFLPT PAKIHYLFNL RDISKVFQGM LRANKDFHDT 2580
KASITRLWIH ECFRVFSDRL VDTTDMEAFI GILSDKLGTF FDLTFHHLCP NKRPPIFGDF 2640
LKEPKVYEDL VDLSVLKTAM ETALNEYNLS PSVVQMQLVL FREAIEHITR IVRVIGQPRG 2700
NMLLVGIGGS GRQSLARLAS SICEYNTFQI EVTKHYRKQE FRDDIKRLYR QAGVELQATS 2760
FLFVDTQIAD ESFLEDINNI LSSGEVPNLY KADEFEEIQN QIIDQARAEQ ISESSDSLFA 2820
YLIERVRNNL HIVLCLSPVG DPFRNWIRQY PALVNCTTIN WFSEWPREAL LEVAEKYLVG 2880
VDLGTQENIH RKVAQIFVTM HWSVAQYSQK MLLELRRHNY VTPTNYLELV SGYKKLLGEK 2940
RQELLDQANK LRTGLFKIDE TREKVEVMSL ELEDAKKKVA EFQKQCEEYL VIIVQQKREA 3000
DEQQKAVTAN SEKIAIEEVK CQALADNAQK DLEEALPALE EAMRALESLN KKDIGEIKSY 3060
GRPPAQVEIV MQAVMILRGN EPTWAEAKRQ LGEQNFIKSL IYFDKDNISD KVLKKIGAYC 3120
AQPDFQPDII GRVSLAAKSL CMWVRAMELY GRLYRVVEPK RIRMNAAIAQ LQEKQAALAE 3180
AQEKLREVAE KLEMLKKQYD EKLAQKEELR KKSEEMELKL ERAGMLVSGL AGEKARWEET 3240
VQGLEEDLGY LVGDCLIAAA FLSYMGPFLT NYRDEIVNQI WIKKIWELQV PCSPRFAIDN 3300
FLTNPTKVRD WNIQGLPSDS FSTENGIIVT RGNRWALMID PQAQALKWIK NMEGNQGLKI 3360
IDLQMHDYLR VLEHAIQFGF PVLLQNVQEY LDPSLNPVLN KSVARIGGRM LMRIADKEVE 3420
YNPNFRFYLT TKLSNPHYSP ETSAKTTIVN FAVKEQGLEA QLLGIVVRKE RPELEEQKDS 3480
LVINIAAGKR KLKELEDEIL RLLNEATGSL LDDVQLVNTL QTSKITATEV TEQLETSETT 3540
EINIDLAREA YRPCAQRASV LFFVLNDMGR IDPMYQFSLD AYISLFILSI DKSHRSNKLE 3600
DRIEYLNDYH TYAVYRYTCR TLFERHKLLF SFHMCAKILE TSGKLNMDEY NFFLRGGVVL 3660
DREGQMDNPC TSWLADAYWD NITELDKLTN FHGLMNSFEQ YPRDWHLWYT NSNPEKAMLP 3720
GEWENACNEM QRMLIVRSLR QDRVAFCVTS FIVSNLGSRF IEPPVLNMKL VMEDSTPRSP 3780
LVFILSPGVD PTSALLQLAE HTGMAHRFHA LSLGQGQAPI AARLLREGVN QGHWVFLANC 3840
HLSLSWMPNL DKLVEQLQVE DPHPSFRLWL SSSPHPDFPI SILQASIKMT TEPPKGLKAN 3900
MTRLYQLMTE AQFTHCSKPT KYKKLLFALC FFHSILLERK KFLQLGWNII YGFNDSDFEV 3960
SENLLSLYLD EYEETPWDAL KYLIAGVNYG GHVTDDWDRR LLTTYINDYF CDLSLTTPSY 4020
RLSVLDTYYI PKDGSLASYK EYISLLPSMD PPEAFGQHPN ADVASQITEA RTLFETLLSL 4080
QPQITPTRIG GQSREEKVLE LAADVKQKIP EMIDYEGTRK LLALDPSPLN VVLLQEIQRY 4140
NKLMKTILFS LTDLEKGIQG LIVMSTSLEE IFNCIFDAHV PPLWGKVYPS QKPLASWTRD 4200
LAVRVEQFET WANRAHPPVL FWLSGFTFPT GFLTAVLQSA ARQNNISVDS LSWEFIVSTV 4260
DDSNLVYPPK DGVWVRGLYL EGAGWDRKNS CLVEAEPMQL VCLMPTIHFR PAESRKKSAK 4320
GMYSCPCYYY PNRAGSADRA SFVIGIDLRS GAMTSDHWIK RGTALLMSLD N 4371 
Gene Ontology
 GO:0005858; C:axonemal dynein complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR026976; DNAH2.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS