CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 4 
Protein Synonyms/Alias
  
Gene Name
 DOCK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89RDWGTMWKQLYVRNEubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1999 AA 
Protein Sequence
XIASFRGTVP YGLSLEIGDT VQILEKCDGW YRGFALKNPN IKGIFPSSYV HLKNACVKNK 60
GQFEMVIPTE DSVITEMTST LRDWGTMWKQ LYVRNEGDLF HRLWHIMNEI LDLRRQVLVG 120
HLTHDRMKDV KRHITARLDW GNEQLGLDLV PRKEYAMVDP EDISITELYR LMEHRHRKKD 180
TPVQASSHHL FVQMKSLMCS NLGEELEVIF SLFDSKENRP ISERFFLRLN RNGLPKAPDK 240
PERHCSLFVD LGSSELRKDI YITVHIIRIG RMGAGEKKNA CSVQYRRPFG CAVLSIADLL 300
TGETKDDLIL KVYMCNTESE WYQIHENIIK KLNARYNLTG SNAGLAVSLQ LLHGDIEQIR 360
REYSSVFSHG VSITRKLGFS NIIMPGEMRN DLYITIERGE FEKGGKSVAR NVEVTMFIVD 420
SSGQTLKDFI SFGSGEPPAS EYHSFVLYHN NSPRWSELLK LPIPVDKFRG AHIRFEFRHC 480
STKEKGEKKL FGFSFVPLMQ EDGRTLPDGT HELIVHKCEE NTNLQDTTRY LKLPFSKGIF 540
LGNNNQAMKA TKESFCITSF LCSTKLTQNG DMLDLLKWRT HPDKITGCLS KLKEIDGSEI 600
VKFLQDTLDT LFGILDENSQ KYGSKVFDSL VHIINLLQDS KFHHFKPVMD TYIESHFAGA 660
LAYRDLIKVL KWYVDRITEA ERQEHIQEVL KAQEYIFKYI VQSRRLFSLA TGGQNEEEFR 720
CCIQELLMSV RFFLSQESKG SGALSQSQAV FLSSFPAVYS ELLKLFDVRE VANLVQDTLG 780
SLPTILHVDD SLQAIKLQCI GKTVESQLYT NPDSRYILLP VVLHHLHIHL QEQKDLIMCA 840
RILSNVFCLI KKNSSEKSVL EEIDVIVASL LDILLRTILE ITSRPQPSSS AMRFQFQDVT 900
RTGFLNRESS HGSTTLSTFS VCADTYGKVP MTSRHTGEFV ACLLSLLRQM TDRHYQQLLD 960
SFNTKEELRD FLLQIFTVFR ILIRPEMFPK DWTVMRLVAN NVIITTVLYL SDALRKNFLN 1020
ENFDYKIWDS YFYLAVIFIN QLCLQLEMFT PSKKKKVLEK YGDMRVTMGC EIFSMWQNLG 1080
EHKLHFIPAL IGPFLEVTLI PQPDLRNVMI PIFHDMMDWE QRRSGNFKQV EAKLIDKLDS 1140
LMSEGKGDET YRELFNSIIP LFGPYPSLLK KIERETWRES GVSLIATVTR LMERLLDYRD 1200
CMKMGEVDGK KIGCTVSLLN FYKTELNKEE MYIRYIHKLY DLHLKAQNFT EAAYTLLLYD 1260
ELLEWSDRPL REFLTYPMQT EWQRKEHLHL TIIQNFDRGK CWENGIILCR KIAEQYESYY 1320
DYRNLSKMRM MEASLYDKIM DQQRLEPEFF RVGFYGKKFP FFLRNKEFVC RGHDYERLEA 1380
FQQRMLNEFP HAIAMQHANQ PDETIFQAEA QYLQIYAVTP IPESQEVLQR EGVPDNIKSF 1440
YKVNHIWKFR YDRPFHKGTK DKENEFKSLW VERTSLYLVQ SLPGISRWFE VEKREVVEMS 1500
PLENAIEVLE NKNQQLKTLI SQCQTRQMQN INPLTMCLNG VIDAAVNGGV SRYQEAFFVK 1560
EYILSHPEDG EKIARLRELM LEQAQILEFG LAVHEKFVPQ DMRPLHKKLV DQFFVMKSSL 1620
GIQEFSACMQ ASPVHFPNGS PRVCRNSAPA SVSPDGTRVI PRRSPLSYPA VNRYSSSSLS 1680
SQASAEVSNI TGQSESSDEV FNMQPSPSTS SLSSTHSASP NVTSSAPSSA RASPLLSDKH 1740
KHSRENSCLS PRERPCSAIY PTPVEPSQRM LFNHIGDGAL PRSDPNLSAP EKAVNPTPSS 1800
WSLDSGKEAK NMSDSGKLIS PPVPPRPTQT ASPARHTTSV SPSPAGRSPL KGSVQSFTPS 1860
PVEYHSPGLI SNSPVLSGSY SSGISSLSRC STSETSGFEN QVNEQSAPLP VPVPVPVPSY 1920
GGEEPVRKES KTPPPYSVYE RTLRRPVPLP HSLSIPVTSE PPALPPKPLA ARSSHLENGA 1980
RRTDPGPRPR PLPRKVSQL 1999 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR026800; DOCK_B.
 IPR010703; DOCK_C.
 IPR001452; SH3_domain. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2 
SMART
 SM00326; SH3 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50002; SH3 
PRINTS