UniProt Accession

 HPRT_ECOLI; P0A9M2; P36766 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC73236.2; BAB96700.2 

Protein Name

 Hypoxanthine phosphoribosyltransferase 

Protein Synonyms/Alias

 HPRT 

Gene Name

 hpt 

Gene Synonyms/Alias

 b0125; JW5009 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
15	MIPEAEIKARIAELG	acetylation	[1]
30	RQITERYKDSGSDMV	acetylation	[1]
84	TRDVKILKDLDEDIR	acetylation	[1]
110	DSGNTLSKVREILSL	acetylation	[1]
121	ILSLREPKSLAICTL	acetylation	[1]
131	AICTLLDKPSRREVN	acetylation	[1]
172	RHLPYIGKVILLDE*	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. 

Sequence Annotation

 NP_BIND 99 108 IMP.
 NP_BIND 158 159 IMP.
 ACT_SITE 103 103 Proton acceptor (Probable).
 METAL 159 159 Magnesium (By similarity).
 BINDING 131 131 IMP.
 BINDING 153 153 IMP; via carbonyl oxygen.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Glycosyltransferase; Magnesium; Metal-binding; Nucleotide-binding; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0052657; F:guanine phosphoribosyltransferase activity; IEA:EC.
 GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0006168; P:adenine salvage; IBA:RefGenome.
 GO:0032263; P:GMP salvage; IDA:EcoliWiki.
 GO:0006178; P:guanine salvage; IBA:RefGenome.
 GO:0046100; P:hypoxanthine metabolic process; IBA:RefGenome.
 GO:0032264; P:IMP salvage; IDA:EcoliWiki.
 GO:0006166; P:purine ribonucleoside salvage; IBA:RefGenome. 

Interpro

 IPR005904; Hxn_phspho_trans.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS