CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium/potassium-transporting ATPase subunit alpha-2 
Protein Synonyms/Alias
  
Gene Name
 Atp1a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
622GDHPITAKAIAKGVGubiquitination[1]
626ITAKAIAKGVGIISEubiquitination[1]
658QVNPREAKACVVHGSubiquitination[1]
668VVHGSDLKDMTSEQLubiquitination[1]
695ARTSPQQKLIIVEGCubiquitination[1]
723VNDSPALKKADIGIAubiquitination[1]
724NDSPALKKADIGIAMubiquitination[1]
770RLIFDNLKKSIAYTLubiquitination[1]
840PRNSQTDKLVNERLIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 947 AA 
Protein Sequence
MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG RKYQVDLSKG 60
LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI LLWIGALLCF LAYGILAAME 120
DEPSNDNLYL GIVLAAVVIV TGCFSYYQEA KSSKIMDSFK NMVPQQALVI REGEKMQINA 180
EEVVVGDLVE VKGGDRVPAD LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI 240
CFFSTNCVEG TARGIVIATG DRTVMGRIAT LASGLEVGQT PIAMEIEHFI QLITGVAVFL 300
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA RKNCLVKNLE 360
AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT TEDQSGATFD KRSPTWTALS 420
RIAGLCNRAV FKAGQENISV SKRDTAGDAS ESALLKCIEL SCGSVRKMRD RNPKVAEIPF 480
NSTNKYQLSI HEREDSPQSH VLVMKGAPER ILDRCSTILV QGKEIPLDKE MQDAFQNAYM 540
ELGGLGERVL GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV 600
GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPREAKAC 660
VVHGSDLKDM TSEQLDEILR DHTEIVFART SPQQKLIIVE GCQRQGAIVA VTGDGVNDSP 720
ALKKADIGIA MGISGSDVSK QAADMILLDD NFASIVTGVE EGRLIFDNLK KSIAYTLTSN 780
IPEITPFLLF IIANIPLPLG TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNSQTDK 840
LVNERLISMA YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR TTNDLEDSYG 900
QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMK 947 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0043197; C:dendritic spine; IEA:Compara.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0040011; P:locomotion; IMP:MGI.
 GO:0045822; P:negative regulation of heart contraction; IMP:MGI.
 GO:0045988; P:negative regulation of striated muscle contraction; IMP:MGI.
 GO:0001504; P:neurotransmitter uptake; IMP:MGI.
 GO:0051481; P:reduction of cytosolic calcium ion concentration; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IGI:MGI.
 GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Compara.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0019229; P:regulation of vasoconstriction; IMP:MGI.
 GO:0035094; P:response to nicotine; IEA:Compara.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR005775; ATPase_P-typ_Na/K_IIC.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.