CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho GTPase activating protein 22, isoform CRA_a 
Protein Synonyms/Alias
 Rho GTPase-activating protein 22 
Gene Name
 ARHGAP22 
Gene Synonyms/Alias
 hCG_2042896 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
539ELDQEKKKYIMLEIKmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 589 AA 
Protein Sequence
MASSQRDMED WVQAIRRVIW APLGGGTARR SHAHPLEPLP PGIFGQRLEE TVHHERKYGP 60
RLAPLLVEQC VDFIRERGLT EEGLFRMPGQ ANLVRDLQDS FDCGEKPLFD STTDVHTVAS 120
LLKLYLRELP EPVVPFARYE DFLSCAQLLT KDEGEGTLEL AKQVSNLPQA NYNLLRYICK 180
FLDEVQAYSN VNKMSVQNLA TVFGPNILRP QVEDPVTIME GTSLVQHLMT VLIRKHSQLF 240
TAPVPEGPTS PRGGLQCAVG WGSEEVTRDS QGEPGGPGLP AHRTSSLDGA AVAVLSRTAP 300
TGPGSRCSPG KKVQTLPSWK SSFRQPRSLS GSPKGGGSSL EVPIISSGGN WLMNGLSSLR 360
GHRRASSGDR LKDSGSVQRL STYDNVPAPG LVPGIPSVAS MAWSGASSSE SSVGGSLSSC 420
TACRASDSSA RSSLHTDWAL EPSPLPSSSE DPKSLDLDHS MDEAGAGASN SEPSEPDSPT 480
REHARRSEAL QGLVTELRAE LCRQRTEYER SVKRIEEGSA DLRKRMSRLE EELDQEKKKY 540
IMLEIKLRNS ERAREDAERR NQLLQREMEE FFSTLGSLTV GAKGARAPK 589 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00620; RhoGAP 
SMART
 SM00324; RhoGAP 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS