CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002152
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Catalase 
Protein Synonyms/Alias
  
Gene Name
 Cat 
Gene Synonyms/Alias
 Cas1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
13DPASDQMKQWKEQRAacetylation[1]
16SDQMKQWKEQRAPQKacetylation[1]
23KEQRAPQKPDVLTTGacetylation[1]
38GGNPIGDKLNIMTAGacetylation[1]
98ITRYSKAKVFEHIGKacetylation[1]
105KVFEHIGKRTPIAVRacetylation[1]
169PSFIHSQKRNPQTHLacetylation[1]
237VYCKFHYKTDQGIKNacetylation[1]
243YKTDQGIKNLPVEEAacetylation[1]
306LTKVWPHKDYPLIPVacetylation[1]
315YPLIPVGKLVLNRNPacetylation[1]
449QVRTFYTKVLNEEERacetylation[1]
457VLNEEERKRLCENIAacetylation[1]
480FIQRKAVKNFTDVHPacetylation[1]
504LDQYNSQKPKNAIHTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. 
Sequence Annotation
 ACT_SITE 75 75 By similarity.
 ACT_SITE 148 148 By similarity.
 METAL 358 358 Iron (heme axial ligand) (By similarity).
 MOD_RES 517 517 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding; Mitogen; NADP; Oxidoreductase; Peroxidase; Peroxisome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 527 AA 
Protein Sequence
MADSRDPASD QMKQWKEQRA PQKPDVLTTG GGNPIGDKLN IMTAGPRGPL LVQDVVFTDE 60
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF EHIGKRTPIA VRFSTVAGES 120
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAML FPSFIHSQKR NPQTHLKDPD 180
MVWDFWSLCP ESLHQVTFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ 240
GIKNLPVEEA GRLAQEDPDY GLRDLFNAIA SGNYPSWTFY IQVMTFKEAE TFPFNPFDLT 300
KVWPHKDYPL IPVGKLVLNR NPANYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFAYPD 360
THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG APNYYPNSFS APEQQGSALE 420
HHSQCSADVK RFNSANEDNV TQVRTFYTKV LNEEERKRLC ENIANHLKDA QLFIQRKAVK 480
NFTDVHPDYG ARVQALLDQY NSQKPKNAIH TYVQAGSHIA AKGKANL 527 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IDA:RGD.
 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0005764; C:lysosome; IDA:RGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0004046; F:aminoacylase activity; IEA:Compara.
 GO:0004096; F:catalase activity; IDA:RGD.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0009060; P:aerobic respiration; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0020027; P:hemoglobin metabolic process; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD.
 GO:0001822; P:kidney development; IMP:RGD.
 GO:0042697; P:menopause; IEP:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0055093; P:response to hyperoxia; IEP:RGD.
 GO:0001666; P:response to hypoxia; IMP:RGD.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara.
 GO:0001657; P:ureteric bud development; IMP:RGD.
 GO:0009650; P:UV protection; IEA:Compara. 
Interpro
 IPR018028; Catalase.
 IPR020835; Catalase-like_dom.
 IPR024708; Catalase_AS.
 IPR024711; Catalase_clade1/3.
 IPR011614; Catalase_core.
 IPR002226; Catalase_haem_BS.
 IPR010582; Catalase_immune_responsive. 
Pfam
 PF00199; Catalase
 PF06628; Catalase-rel 
SMART
 SM01060; Catalase 
PROSITE
 PS00437; CATALASE_1
 PS00438; CATALASE_2
 PS51402; CATALASE_3 
PRINTS
 PR00067; CATALASE.