CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020666
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cysteine-rich with EGF-like domain protein 2 
Protein Synonyms/Alias
  
Gene Name
 Creld2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
38RCRTLVDKFNQGMANacetylation[1]
65WEEKTLSKYEFSEIRacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
 May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). 
Sequence Annotation
 DOMAIN 134 176 EGF-like 1.
 REPEAT 191 238 FU 1.
 REPEAT 251 298 FU 2.
 DOMAIN 288 329 EGF-like 2; calcium-binding (Potential).
 CARBOHYD 249 249 N-linked (GlcNAc...) (Potential).
 DISULFID 138 152 By similarity.
 DISULFID 146 164 By similarity.
 DISULFID 166 175 By similarity.
 DISULFID 292 306 By similarity.
 DISULFID 299 315 By similarity.
 DISULFID 317 328 By similarity.  
Keyword
 Calcium; Complete proteome; Disulfide bond; EGF-like domain; Endoplasmic reticulum; Glycoprotein; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MHLLLAAAFG LLLLLPPPGA VASRKPTMCQ RCRTLVDKFN QGMANTARKN FGGGNTAWEE 60
KTLSKYEFSE IRLLEIMEGL CDSSDFECNQ LLEQQEEQLE AWWQTLKKEH PNLFEWFCVH 120
TLKACCLPGT YGPDCQECQG GSERPCSGNG YCSGDGSRQG DGSCQCHTGY KGPLCIDCTD 180
GFFSLQRNET HSICSACDES CKTCSGPSNK DCIQCEVGWA RVEDACVDVD ECAAETSPCS 240
DGQYCENVNG SYTCEDCDST CVGCTGKGPA NCKECIAGYT KESGQCTDID ECSLEEKACK 300
RKNENCYNVP GSFVCVCPEG FEETEDACVQ TAEGKVTEEN PTQPPSREDL 350 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR021852; DUF3456.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR002049; EGF_laminin.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom. 
Pfam
 PF11938; DUF3456
 PF07645; EGF_CA 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00261; FU 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA 
PRINTS