CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010866
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoglycerate kinase 
Protein Synonyms/Alias
  
Gene Name
 Pgk 
Gene Synonyms/Alias
 CG3127 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
29VDFNVPIKEGKITSNacetylation[1]
73PDGNKNIKYTLAPVAacetylation[1]
129FYVEEEGKGLDASGGacetylation[1]
266EGSKIVEKLVEKAKKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
 NP_BIND 371 374 ATP (By similarity).
 REGION 23 25 Substrate binding (By similarity).
 REGION 62 65 Substrate binding (By similarity).
 BINDING 38 38 Substrate (By similarity).
 BINDING 121 121 Substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 218 218 ATP (By similarity).
 BINDING 311 311 ATP; via carbonyl oxygen (By similarity).
 BINDING 342 342 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MAFNKLSIEN LDLAGKRVLM RVDFNVPIKE GKITSNQRIV AALDSIKLAL SKKAKSVVLM 60
SHLGRPDGNK NIKYTLAPVA AELKTLLGQD VIFLSDCVGS EVEAACKDPA PGSVILLENV 120
RFYVEEEGKG LDASGGKVKA DPAKVKEFRA SLAKLGDVYV NDAFGTAHRA HSSMMGDGFE 180
QRAAGLLLNK ELKYFSQALD KPPNPFLAIL GGAKVADKIQ LIENLLDKVN EMIIGGGMAF 240
TFLKVLNNMK IGGSLFDEEG SKIVEKLVEK AKKNNVQLHL PVDFVCGDKF AENAAVSEAT 300
VEAGIPDGHM GLDVGPKTRE LFAAPIARAK LIVWNGPPGV FEFPNFANGT KSIMDGVVAA 360
TKNGTVSIIG GGDTASCCAK WNTEALVSHV STGGGASLEL LEGKTLPGVA ALTSA 415 
Gene Ontology
 GO:0031430; C:M band; IDA:FlyBase.
 GO:0030018; C:Z disc; IDA:FlyBase.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
 GO:0046716; P:muscle cell homeostasis; IGI:FlyBase.
 GO:0007268; P:synaptic transmission; IDA:FlyBase. 
Interpro
 IPR001576; Phosphoglycerate_kinase.
 IPR015901; Phosphoglycerate_kinase_C.
 IPR015911; Phosphoglycerate_kinase_CS.
 IPR015824; Phosphoglycerate_kinase_N. 
Pfam
 PF00162; PGK 
SMART
  
PROSITE
 PS00111; PGLYCERATE_KINASE 
PRINTS
 PR00477; PHGLYCKINASE.