CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038311
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family G member 8 
Protein Synonyms/Alias
  
Gene Name
 Abcg8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2******MKSGQIWINubiquitination[1]
215REVATVEKAQSLAALubiquitination[1]
236GFDDFLWKAEAKELNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MKSGQIWING QPSTPQLVRK CVAHVRQHDQ LLPNLTVRET LAFIAQMRLP RTFSQAQRDK 60
RVEDVIAELR LRQCANTRVG NTYVRGVSGG ERRRVSIGVQ LLWNPGILIL DEPTSGLDSF 120
TAHNLVTTLS RLAKGNRLVL ISLHQPRSDI FRLFDLVLLM TSGTPIYLGA AQQMVQYFTS 180
IGHPCPRYSN PADFYVDLTS IDRRSKEREV ATVEKAQSLA ALFLEKVQGF DDFLWKAEAK 240
ELNTSTHTVS LTLTQDTDCG TAVELPGMIE QFSTLIRRQI SNDFRDLPTL LIHGSEACLM 300
SLIIGFLYYG HGAKQLSFMD TAALLFMIGA LIPFNVILDV VSKCHSERSM LYYELEDGLY 360
TAGPYFFAKI LGELPEHCAY VIIYAMPIYW LTNLRPVPEL FLLHFLLVWL VVFCCRTMAL 420
AASAMLPTFH MSSFFCNALY NSFYLTAGFM INLDNLWIVP AWISKLSFLR WCFSGLMQIQ 480
FNGHLYTTQI GNFTFSILGD TMISAMDLNS HPLYAIYLIV IGISYGFLFL YYLSLKLIKQ 540
KSIQDW 546 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0007588; P:excretion; IEA:Compara.
 GO:0045796; P:negative regulation of intestinal cholesterol absorption; IEA:Compara.
 GO:0010949; P:negative regulation of intestinal phytosterol absorption; IEA:Compara.
 GO:0015914; P:phospholipid transport; IMP:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0015918; P:sterol transport; IMP:MGI. 
Interpro
 IPR013525; ABC_2_trans.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01061; ABC2_membrane
 PF00005; ABC_tran 
SMART
  
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS