UniProt Accession

 PHKG1_RAT; P13286 

Genbank Protein ID

 X07320 

Genbank Nucleotide ID

 CAA30280.1 

Protein Name

 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 

Protein Synonyms/Alias

 Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1 

Gene Name

 Phkg1 

Gene Synonyms/Alias

 Phkg 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
23	FYENYEPKEILGRGV	acetylation	[1]
361	IYGHWVKKGQQQNRA	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). 

Sequence Annotation

 DOMAIN 20 288 Protein kinase.
 NP_BIND 26 34 ATP (By similarity).
 REGION 303 327 Calmodulin-binding (domain-N).
 REGION 343 367 Calmodulin-binding (domain-C).
 ACT_SITE 150 150 Proton acceptor (By similarity).
 BINDING 49 49 ATP (By similarity).  

Keyword

 ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Muscle protein; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 388 AA 

Protein Sequence

Gene Ontology

 GO:0005964; C:phosphorylase kinase complex; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0019899; F:enzyme binding; IDA:RGD.
 GO:0004689; F:phosphorylase kinase activity; IDA:RGD.
 GO:0050321; F:tau-protein kinase activity; IEA:EC.
 GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
 GO:0005977; P:glycogen metabolic process; IDA:RGD. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR011009; Kinase-like_dom.
 IPR002291; Phosph_kin_gamma.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS

 PR01049; PHOSPHBKNASE.