UniProt Accession

 NDUS7_MOUSE; Q9DC70 

Genbank Protein ID

 AK003132; BC013503 

Genbank Nucleotide ID

 BAB22592.1; AAH13503.1 

Protein Name

 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 

Protein Synonyms/Alias

 Complex I-20kD; CI-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit 

Gene Name

 Ndufs7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	GAGAVVPKLSHLPRS	acetylation	[1, 2, 3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 METAL 99 99 Iron-sulfur (4Fe-4S) (Potential).
 METAL 100 100 Iron-sulfur (4Fe-4S) (Potential).
 METAL 164 164 Iron-sulfur (4Fe-4S) (Potential).
 METAL 194 194 Iron-sulfur (4Fe-4S) (Potential).  

Keyword

 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0097060; C:synaptic membrane; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
 GO:0048038; F:quinone binding; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB. 

Interpro

 IPR006137; NADH_UbQ_OxRdtase-like_20kDa.
 IPR006138; NADH_UQ_OxRdtase_20Kd_su.
 IPR014406; NiFe-hyd_3_ssu/Q_oxred_NuoB. 

Pfam

 PF01058; Oxidored_q6 

SMART

  

PROSITE

 PS01150; COMPLEX1_20K 

PRINTS