CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 1F 
Protein Synonyms/Alias
 Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Protein fem-2 homolog; hFem-2 
Gene Name
 PPM1F 
Gene Synonyms/Alias
 KIAA0015; POPX2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70MGFLGSRKAPPPLAAubiquitination[1]
142EVAGQWQKQVPLAARubiquitination[1, 2]
334AIGDVFQKPYVSGEAubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. 
Sequence Annotation
 METAL 198 198 Manganese 1 (By similarity).
 METAL 198 198 Manganese 2 (By similarity).
 METAL 199 199 Manganese 1; via carbonyl oxygen (By
 METAL 360 360 Manganese 2 (By similarity).
 METAL 404 404 Manganese 2 (By similarity).  
Keyword
 Apoptosis; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Polymorphism; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MSSGAPQKSS PMASGAEETP GFLDTLLQDF PALLNPEDPL PWKAPGTVLS QEEVEGELAE 60
LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPR EEEEEEEDDD EEEKAPVTLL 120
DAQSLAQSFF NRLWEVAGQW QKQVPLAARA SQRQWLVSIH AIRNTRRKME DRHVSLPSFN 180
QLFGLSDPVN RAYFAVFDGH GGVDAARYAA VHVHTNAARQ PELPTDPEGA LREAFRRTDQ 240
MFLRKAKRER LQSGTTGVCA LIAGATLHVA WLGDSQVILV QQGQVVKLME PHRPERQDEK 300
ARIEALGGFV SHMDCWRVNG TLAVSRAIGD VFQKPYVSGE ADAASRALTG SEDYLLLACD 360
GFFDVVPHQE VVGLVQSHLT RQQGSGLRVA EELVAAARER GSHDNITVMV VFLRDPQELL 420
EGGNQGEGDP QAEGRRQDLP SSLPEPETQA PPRS 454 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0033192; F:calmodulin-dependent protein phosphatase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IDA:UniProtKB.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.
 GO:0044387; P:negative regulation of protein kinase activity by regulation of protein phosphorylation; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0035970; P:peptidyl-threonine dephosphorylation; IDA:UniProtKB.
 GO:0050921; P:positive regulation of chemotaxis; IMP:UniProtKB.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB.
 GO:0051894; P:positive regulation of focal adhesion assembly; IMP:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
 GO:0045927; P:positive regulation of growth; IMP:UniProtKB.
 GO:0051496; P:positive regulation of stress fiber assembly; IDA:UniProtKB. 
Interpro
 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 
Pfam
 PF00481; PP2C 
SMART
 SM00331; PP2C_SIG
 SM00332; PP2Cc 
PROSITE
 PS01032; PP2C 
PRINTS