UniProt Accession

 EIF3D_MOUSE; O70194; Q8BLH0; Q8BWW1 

Genbank Protein ID

 AB012580; AK045228; AK049767; AK145689; AK168256; BC089020 

Genbank Nucleotide ID

 BAA25327.1; BAC32270.1; BAC33910.1; BAE26591.1; BAE40204.1; AAH89020.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit D 

Protein Synonyms/Alias

 eIF3d; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta; eIF3 p66 

Gene Name

 Eif3d 

Gene Synonyms/Alias

 Eif3s7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	MPYQPFSKGDRLGKV	ubiquitination	[1]
41	SKGDRLGKVADWTGA	acetylation	[2]
53	TGATYQDKRYTNKYS	acetylation	[2]
53	TGATYQDKRYTNKYS	ubiquitination	[1]
124	FNLQTLPKSAKQKER	acetylation	[2]
171	VRSDWEVKEEMDFPQ	acetylation	[2]
275	VVQRVGSKLFFDKRD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. 

Sequence Annotation

 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 529 529 Phosphoserine.
 MOD_RES 548 548 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IDA:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0001732; P:formation of translation initiation complex; IDA:UniProtKB.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 

Interpro

 IPR007783; eif3d. 

Pfam

 PF05091; eIF-3_zeta 

SMART

  

PROSITE

  

PRINTS