| Tag | Content |
|---|
| CPLM ID | CPLM-014429 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology-like domain family A member 1 |
Protein Synonyms/Alias | Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; T-cell death-associated gene 51 protein |
Gene Name | Phlda1 |
Gene Synonyms/Alias | Tdag51 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 152 | MLENSGCKALKEGVL | ubiquitination | [1] | | 155 | NSGCKALKEGVLEKR | ubiquitination | [1] | | 287 | RQAILAVKSTRQKQQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR- induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation. |
Sequence Annotation | DOMAIN 153 277 PH.
REGION 309 344 16 X 2 AA repeats of P-Q.
REGION 354 377 11 X 2 AA repeats of P-H. |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Membrane; Nucleus; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 405 AA |
Protein Sequence | MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP FSERSPEDGR 60
EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL CALRAGGRGS RWGEDGAGLL 120
LLPPAGASGS LKAERSSSTP YAGRMLENSG CKALKEGVLE KRSDGLLQLW KKKCCILTEE 180
GLLLIPPKQL QQQQQQQQPG QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK 240
GKYMYFTVVM TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ 300
PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP HPHPHPYSHP 360
HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS TSNSA 405 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0045210; P:FasL biosynthetic process; IDA:MGI. GO:0006917; P:induction of apoptosis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |