UniProt Accession

 Q6NX59_HUMAN; Q6NX59 

Genbank Protein ID

 AL096766; AL118516; BC067255; CH471138 

Genbank Nucleotide ID

 AAH67255.1; EAW73440.1 

Protein Name

 CERK protein 

Protein Synonyms/Alias

 Ceramide kinase; Ceramide kinase, isoform CRA_c 

Gene Name

 CERK 

Gene Synonyms/Alias

 hCG_41793 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
275	EDEDSDLKEGGKKRF	ubiquitination	[1, 2, 3]
279	SDLKEGGKKRFGHIC	ubiquitination	[1]
280	DLKEGGKKRFGHICS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR001206; Diacylglycerol_kinase_cat_dom. 

Pfam

 PF00781; DAGK_cat 

SMART

  

PROSITE

 PS50146; DAGK 

PRINTS