| Tag | Content |
|---|
| CPLM ID | CPLM-016889 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BAG family molecular chaperone regulator 5 |
Protein Synonyms/Alias | BAG-5; Bcl-2-associated athanogene 5 |
Gene Name | Bag5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | RLERILTKQLFEIDS | ubiquitination | [1] | | 404 | RLEELLTKQLLALDA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). |
Sequence Annotation | DOMAIN 9 86 BAG 1.
DOMAIN 95 167 BAG 2.
DOMAIN 182 260 BAG 3.
DOMAIN 275 350 BAG 4.
DOMAIN 365 442 BAG 5. |
Keyword | 3D-structure; Chaperone; Complete proteome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 447 AA |
Protein Sequence | MDMGNQHPSI SRLQEIQREV KAIEPQVVGF SGLSDDKNYK RLERILTKQL FEIDSVDTEG 60
KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFKE AQALVKDKIV PFYSGGNCVT 120
DEFEEGIQDI ILRLTHVKTG GKVSLRKARY RTLTKICAVQ EVIEDCMKKQ PSLPLSEDVH 180
PSVAKINSVM CEVNKARGTL IALLMGVDSS ETCRHLSCVL SGLIADLDAL DVCGRTEIRN 240
YRREVVEDIN KLLKYLDLEE EADSTHAFDL GQNHSIIKIE NVLKRMREIK NELLQAQSPP 300
ELYLRAKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ ILITYLDLKE ALEKRKLFPC 360
EEHPPHKAVW EILGNLSEIL GEVLSFGGNR TDKNYIRLEE LLTKQLLALD AVDPQGEEKC 420
KAARKQAVKL AQNILSYLDM KSDEWEY 447 |
Gene Ontology | GO:0016234; C:inclusion body; ISS:BHF-UCL. GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL. GO:0051087; F:chaperone binding; ISS:BHF-UCL. GO:0061084; P:negative regulation of protein refolding; ISS:BHF-UCL. GO:0051444; P:negative regulation of ubiquitin-protein ligase activity; ISS:BHF-UCL. GO:0070997; P:neuron death; ISS:BHF-UCL. GO:0090083; P:regulation of inclusion body assembly; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |