UniProt Accession

 CYS3_YEAST; P31373; D6VPK6 

Genbank Protein ID

 L05146; D14135; BK006935 

Genbank Nucleotide ID

 AAC04945.1; BAA03190.1; DAA06976.1 

Protein Name

 Cystathionine gamma-lyase 

Protein Synonyms/Alias

 Gamma-cystathionase; Sulfur transfer protein 1 

Gene Name

 CYS3 

Gene Synonyms/Alias

 CYI1; STR1; YAL012W; FUN35 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
113	GTHRYFTKVANAHGV	ubiquitination	[1]
160	LKVTDIQKVADLIKK	acetylation	[2]
267	QAALSANKIAEFLAA	acetylation	[2]
288	AVNYPGLKTHPNYDV	acetylation	[2]
298	PNYDVVLKQHRDALG	acetylation	[2]
322	GGAEAASKFASSTRL	acetylation	[2]
356	MTHGGIPKEAREASG	ubiquitination	[1]
390	EDIKQALKQATN***	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 BINDING 52 52 Substrate (By similarity).
 BINDING 104 104 Substrate (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 334 334 Substrate (By similarity).
 MOD_RES 204 204 N6-(pyridoxal phosphate)lysine (By
 MOD_RES 362 362 Phosphoserine.  

Keyword

 3D-structure; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Cytoplasm; Direct protein sequencing; Lyase; Phosphoprotein; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004123; F:cystathionine gamma-lyase activity; IDA:SGD.
 GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.
 GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:SGD.
 GO:0019346; P:transsulfuration; IMP:SGD. 

Interpro

 IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF01053; Cys_Met_Meta_PP 

SMART

  

PROSITE

 PS00868; CYS_MET_METAB_PP 

PRINTS