CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041877
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat domain 17, isoform CRA_c 
Protein Synonyms/Alias
 Tetratricopeptide repeat protein 17 
Gene Name
 TTC17 
Gene Synonyms/Alias
 hCG_15140 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80EATVNYLKELEKQLVubiquitination[1]
239ASFYWRIKNEPYQVVubiquitination[1]
347CQQKLEQKLEAQHRSubiquitination[1]
367NELKEYQKQHDHYLRubiquitination[1]
383QEILEKHKLIQEEQIubiquitination[1]
529YFLPPENKGLRIHELubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 956 AA 
Protein Sequence
MAAAVGVRGR YELPPCSGPG WLLSLSALLS VAARGAFATT HWVVTEDGKI QQQVDSPMNL 60
KHPHDLVILM RQEATVNYLK ELEKQLVAQK IHIEENEDRD TGLEQRHNKE DPDCIKAKVP 120
LGDLDLYDGT YITLESKDIS PEDYIDTESP VPPDPEQPDC TKILELPYSI HAFQHLRGVQ 180
ERVNLSAPLL PKEDPIFTYL SKRLGRSIDD IGHLIHEGLQ KNTSSWVLYN MASFYWRIKN 240
EPYQVVECAM RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSDFFTSYYT 300
LGNIYAMLGE YNHSVLCYDH ALQARPGFEQ AIKRKHAVLC QQKLEQKLEA QHRSLQRTLN 360
ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM AKEAQLGNHQ ICRLVNQQHS 420
LHCQWDQPVR YHRGDIFENV DYVQFGEDSS TSSMMSVNFD VQSNQSDIND SVKSSPVAHS 480
ILWIWGRDSD AYRDKQHILW PKRADCTESY PRVPVGGELP TYFLPPENKG LRIHELSSDD 540
YSTEEEAQTP DCSITDFRKS HTLSYLVKEL EVRMDLKAKM PDDHARKILL SRINNYTIPE 600
EEIGSFLFHA INKPNAPIWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP LQYQDVPLVN 660
LANLLIHYGL HLDATKLLLQ ALAINSSEPL TFLSLGNAYL ALKNISGALE AFRQALKLTT 720
KCPECENSLK LIRCMQFYPF LYNITSSVCS GNCHEKTLDN SHDKQKYFDN SQSLDAAEEE 780
PSERGTEEDP VFSVENSGRD SDALRLESTV VEESNGSDEM ENSDETKMSE EILALVDEFQ 840
QAWPLEGFGG ALEMKGRRLD LQGIRVLKKG PQDGVARSSC YGDCRSEDDE ATEWITFQVK 900
RVKKPKGDHK KTPGKKVETG QIENGHRYQA NLEITGPKVA SPGPQGLLDW KTRKVP 956 
Gene Ontology
  
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS