| Tag | Content |
|---|
| CPLM ID | CPLM-005622 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UDP-N-acetylglucosamine 2-epimerase |
Protein Synonyms/Alias | Bacteriophage N4 adsorption protein C; UDP-GlcNAc-2-epimerase |
Gene Name | wecB |
Gene Synonyms/Alias | nfrC; rffE; yifF; b3786; JW5600 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | PLVHALAKDPFFEAK | acetylation | [1] | | 205 | YPFIDPDKKMILVTG | acetylation | [1] | | 329 | VRLVGTDKQRIVEEV | acetylation | [1] | | 341 | EEVTRLLKDENEYQA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption. |
Sequence Annotation | ACT_SITE 213 213 Probable. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Isomerase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 376 AA |
Protein Sequence | MKVLTVFGTR PEAIKMAPLV HALAKDPFFE AKVCVTAQHR EMLDQVLKLF SIVPDYDLNI 60
MQPGQGLTEI TCRILEGLKP ILAEFKPDVV LVHGDTTTTL ATSLAAFYQR IPVGHVEAGL 120
RTGDLYSPWP EEANRTLTGH LAMYHFSPTE TSRQNLLREN VADSRIFITG NTVIDALLWV 180
RDQVMSSDKL RSELAANYPF IDPDKKMILV TGHRRESFGR GFEEICHALA DIATTHQDIQ 240
IVYPVHLNPN VREPVNRILG HVKNVILIDP QEYLPFVWLM NHAWLILTDS GGIQEEAPSL 300
GKPVLVMRDT TERPEAVTAG TVRLVGTDKQ RIVEEVTRLL KDENEYQAMS RAHNPYGDGQ 360
ACSRILEALK NNRISL 376 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:EC. GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway. GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro. GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |