UniProt Accession

 SHDAG_HDVD3; P0C6L3 

Genbank Protein ID

 D01075 

Genbank Nucleotide ID

 BAA00874.1 

Protein Name

 Small delta antigen 

Protein Synonyms/Alias

 S-HDAg; p24 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Hepatitis delta virus genotype I (isolate D380) (HDV) 

NCBI Taxa ID

 31762 

Lysine Modification

Position	Peptide	Type	References
72	GEGAPPAKRARTDQM	acetylation	[1]

Reference

 [1] The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis.
 Mu JJ, Tsay YG, Juan LJ, Fu TF, Huang WH, Chen DS, Chen PJ.
 Virology. 2004 Feb 5;319(1):60-70. [PMID: 14967488] 

Functional Description

 Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as a RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity). 

Sequence Annotation

 REGION 12 60 Dimerization (Potential).
 REGION 97 107 RNA-binding (Potential).
 REGION 136 146 RNA-binding (Potential).
 MOTIF 66 75 Nuclear localization signal (By
 MOD_RES 2 2 Phosphoserine; by host CK2.
 MOD_RES 13 13 Omega-N-methylated arginine; by host
 MOD_RES 72 72 N6-acetyllysine; by host.
 MOD_RES 123 123 Phosphoserine; by host.
 MOD_RES 177 177 Phosphoserine; by host MAPK1 and MAPK3.
 MOD_RES 182 182 Phosphothreonine; by host.  

Keyword

 Acetylation; Complete proteome; Host nucleus; Host-virus interaction; Methylation; Phosphoprotein; Reference proteome; RNA editing; RNA-binding; Viral penetration into host nucleus; Virion; Virus entry into host cell. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0019012; C:virion; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
 GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW. 

Interpro

 IPR027403; Delta_antigen_N.
 IPR002506; HDV_ag. 

Pfam

 PF01517; HDV_ag 

SMART

  

PROSITE

  

PRINTS