| Tag | Content |
|---|
| CPLM ID | CPLM-023092 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxisomal carnitine O-octanoyltransferase |
Protein Synonyms/Alias | COT |
Gene Name | CROT |
Gene Synonyms/Alias | COT |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | KTEEIVQKFQSGIGE | ubiquitination | [1] | | 65 | FQSGIGEKLHQKLLE | ubiquitination | [1] | | 167 | RMLFSTCKVPGITRD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester. |
Sequence Annotation | REGION 405 417 Coenzyme A binding (By similarity).
MOTIF 610 612 Microbody targeting signal (Potential).
ACT_SITE 327 327 Proton acceptor (By similarity).
BINDING 439 439 Carnitine (By similarity).
BINDING 442 442 Coenzyme A (By similarity).
BINDING 452 452 Carnitine (By similarity).
BINDING 505 505 Carnitine (By similarity).
MOD_RES 495 495 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Fatty acid metabolism; Lipid metabolism; Peroxisome; Polymorphism; Reference proteome; Transferase; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 612 AA |
Protein Sequence | MENQLAKSTE ERTFQYQDSL PSLPVPSLEE SLKKYLESVK PFANQEEYKK TEEIVQKFQS 60
GIGEKLHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFAGPAAHF EHYWPPKEGT 120
QLERGSITLW HNLNYWQLLR KEKVPVHKVG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF 180
RTESEGRSPN HIVVLCRGRA FVFDVIHEGC LVTPPELLRQ LTYIHKKCHS EPDGPGIAAL 240
TSEERTRWAK AREYLIGLDP ENLALLEKIQ SSLLVYSMED SSPHVTPEDY SEIIAAILIG 300
DPTVRWGDKS YNLISFSNGV FGCNCDHAPF DAMIMVNISY YVDEKIFQNE GRWKGSEKVR 360
DIPLPEELIF IVDEKVLNDI NQAKAQYLRE ASDLQIAAYA FTSFGKKLTK NKMLHPDTFI 420
QLALQLAYYR LHGHPGCCYE TAMTRHFYHG RTETMRSCTV EAVRWCQSMQ DPSVNLRERQ 480
QKMLQAFAKH NKMMKDCSAG KGFDRHLLGL LLIAKEEGLP VPELFTDPLF SKSGGGGNFV 540
LSTSLVGYLR VQGVVVPMVH NGYGFFYHIR DDRFVVACSA WKSCPETDAE KLVQLTFCAF 600
HDMIQLMNST HL 612 |
Gene Ontology | GO:0005782; C:peroxisomal matrix; TAS:Reactome. GO:0008458; F:carnitine O-octanoyltransferase activity; IDA:UniProtKB. GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; TAS:Reactome. GO:0006091; P:generation of precursor metabolites and energy; IDA:UniProtKB. GO:0051791; P:medium-chain fatty acid metabolic process; IDA:UniProtKB. GO:0006810; P:transport; IEA:UniProtKB-KW. |
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