| Tag | Content |
|---|
| CPLM ID | CPLM-006291 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 26S protease regulatory subunit 6A |
Protein Synonyms/Alias | Tat-binding protein homolog 1; TBP-1 |
Gene Name | RPT5 |
Gene Synonyms/Alias | YTA1; YOR117W; O3258; YOR3258W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 35 | QELQTRAKLLDNEIR | ubiquitination | [1] | | 141 | LVDPDKLKPNDLVGV | ubiquitination | [1] | | 175 | KAMEVDEKPTETYSD | ubiquitination | [1] | | 208 | MKRADKFKDMGIRAP | ubiquitination | [1] | | 428 | EVQARKSKSVSFYA* | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). |
Sequence Annotation | NP_BIND 222 229 ATP (Potential).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 180 180 Phosphotyrosine. |
Keyword | 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 434 AA |
Protein Sequence | MATLEELDAQ TLPGDDELDQ EILNLSTQEL QTRAKLLDNE IRIFRSELQR LSHENNVMLE 60
KIKDNKEKIK NNRQLPYLVA NVVEVMDMNE IEDKENSEST TQGGNVNLDN TAVGKAAVVK 120
TSSRQTVFLP MVGLVDPDKL KPNDLVGVNK DSYLILDTLP SEFDSRVKAM EVDEKPTETY 180
SDVGGLDKQI EELVEAIVLP MKRADKFKDM GIRAPKGALM YGPPGTGKTL LARACAAQTN 240
ATFLKLAAPQ LVQMYIGEGA KLVRDAFALA KEKAPTIIFI DELDAIGTKR FDSEKSGDRE 300
VQRTMLELLN QLDGFSSDDR VKVLAATNRV DVLDPALLRS GRLDRKIEFP LPSEDSRAQI 360
LQIHSRKMTT DDDINWQELA RSTDEFNGAQ LKAVTVEAGM IALRNGQSSV KHEDFVEGIS 420
EVQARKSKSV SFYA 434 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008540; C:proteasome regulatory particle, base subcomplex; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; ISS:SGD. GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IMP:SGD. GO:0070682; P:proteasome regulatory particle assembly; IMP:SGD. GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD. |
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