CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008289
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 6A 
Protein Synonyms/Alias
 Cytokeratin-6A; CK-6A; Keratin-6-alpha; mK6-alpha; Keratin-6A; K6A 
Gene Name
 Krt6a 
Gene Synonyms/Alias
 Ker2; Krt2-6; Krt2-6a; Krt6 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
178RFLEQQNKVLDTKWAubiquitination[1]
Reference
 [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144
Functional Description
  
Sequence Annotation
 REGION 1 151 Head.
 REGION 152 461 Rod.
 REGION 152 187 Coil 1A.
 REGION 188 206 Linker 1.
 REGION 207 298 Coil 1B.
 REGION 299 322 Linker 12.
 REGION 323 461 Coil 2.
 REGION 462 553 Tail.  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Keratin; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MSTKTTIKSQ TSHRGYSASS ARVPGLNRSG FSSVSVCRSR GSGGSSAMCG GAGFGSRSLY 60
GVGSSKRISI GGGSCGIGGG YGSRFGGSFG IGGGAGSGFG FGGGAGFGGG YGGAGFPVCP 120
PGGIQEVTIN QSLLTPLNLQ IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL 180
DTKWALLQEQ GTKTVRQNLE PMFEQYISNL RRQLDSIIGE RGRLDSELRN MQDTVEDYKS 240
KYEDEINKRT AAENEFVTLK KDVDAAYMNK VELQAKADSL TDDINFLRAL YEAELSQMQT 300
HISDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIAQRSRAE AESWYQTKYE ELQVTAGRHG 360
DDLRNTKQEI AEINRMIQRL RSEIDHVKKQ CANLQAAIAD AEQRGEMALK DARGKLEGLE 420
DALQKAKQDM ARLLKEYQEL MNVKLALDVE IATYRKLLEG EECRLNGEGV GPVNISVVQS 480
TVSSGYGSAG GASSSLGLGG GSSYSYSSSH GLGGGFSAGS GRAIGGGLSS SGGLSSSTIK 540
YTTTSSSKKS YRQ 553 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0045109; P:intermediate filament organization; IGI:MGI.
 GO:0031424; P:keratinization; IGI:MGI.
 GO:0002009; P:morphogenesis of an epithelium; IGI:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IDA:MGI. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.