CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myelin-oligodendrocyte glycoprotein 
Protein Synonyms/Alias
  
Gene Name
 Mog 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
100RGRTELLKESIGEGKacetylation[1]
107KESIGEGKVALRIQNacetylation[1]
183LQHRLRGKLRAEVENacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. 
Sequence Annotation
 DOMAIN 30 139 Ig-like.
 MOD_RES 123 123 Phosphotyrosine (By similarity).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 DISULFID 51 125 Potential.  
Keyword
 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MAGVWSLSLP SCLLSLLLLL QLSRSYAGQF RVIGPGHPIR ALVGDEAELP CRISPGKNAT 60
GMEVGWYRSP FSRVVHLYRN GKDQDAEQAP EYRGRTELLK ESIGEGKVAL RIQNVRFSDE 120
GGYTCFFRDH SYQEEAAVEL KVEDPFYWIN PGVLALIALV PMLLLQVSVG LVFLFLQHRL 180
RGKLRAEVEN LHRTFDPHFL RVPCWKITLF VIVPVLGPLV ALIICYNWLH RRLAGQFLEE 240
LRNPF 245 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0034126; P:positive regulation of MyD88-dependent toll-like receptor signaling pathway; IMP:BHF-UCL. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR016663; Myelin-oligodendrocyte_glycop. 
Pfam
 PF07686; V-set 
SMART
 SM00406; IGv 
PROSITE
 PS50835; IG_LIKE 
PRINTS