| Tag | Content |
|---|
| CPLM ID | CPLM-022340 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | tRNA (guanine(26)-N(2))-dimethyltransferase |
Protein Synonyms/Alias | tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase |
Gene Name | TRMT1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 283 | KYGAMALKSRACHEM | ubiquitination | [1] | | 458 | HACKNAVKTDAPASA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
Sequence Annotation | ZN_FING 600 627 C3H1-type.
MOD_RES 120 120 Phosphoserine (By similarity).
MOD_RES 625 625 Phosphoserine.
MOD_RES 628 628 Phosphothreonine.
MOD_RES 646 646 Phosphothreonine. |
Keyword | Alternative splicing; Complete proteome; Metal-binding; Methyltransferase; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 659 AA |
Protein Sequence | MQGSSLWLSL TFRSARVLSR ARFFEWQSPG LPNTAAMENG TGPYGEERPR EVQETTVTEG 60
AAKIAFPSAN EVFYNPVQEF NRDLTCAVIT EFARIQLGAK GIQIKVPGEK DTQKVVVDLS 120
EQEEEKVELK ESENLASGDQ PRTAAVGEIC EEGLHVLEGL AASGLRSIRF ALEVPGLRSV 180
VANDASTRAV DLIRRNVQLN DVAHLVQPSQ ADARMLMYQH QRVSERFDVI DLDPYGSPAT 240
FLDAAVQAVS EGGLLCVTCT DMAVLAGNSG ETCYSKYGAM ALKSRACHEM ALRIVLHSLD 300
LRANCYQRFV VPLLSISADF YVRVFVRVFT GQAKVKASAR AKFSAACGPP VTPECEHCGQ 360
RHQLGGPMWA EPIHDLDFVG RVLEAVSANP GRFHTSERIR GVLSVITEEL PDVPLYYTLD 420
QLSSTIHCNT PSLLQLRSAL LHADFRVSLS HACKNAVKTD APASALWDIM RCWEKECPVK 480
RERLSETSPA FRILSVEPRL QANFTIREDA NPSSRQRGLK RFQANPEANW GPRPRARPGG 540
KAADEAMEER RRLLQNKRKE PPEDVAQRAA RLKTFPCKRF KEGTCQRGDQ CCYSHSPPTP 600
RVSADAAPDC PETSNQTPPG PGAAAGPGID 630 |
Gene Ontology | GO:0003723; F:RNA binding; IEA:InterPro. GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |