UniProt Accession

 PTSS2_HUMAN; Q9BVG9 

Genbank Protein ID

 AL834357; AC137894; AC138230; BC001210 

Genbank Nucleotide ID

 CAD39022.1; AAH01210.1 

Protein Name

 Phosphatidylserine synthase 2 

Protein Synonyms/Alias

 PSS-2; PtdSer synthase 2; Serine-exchange enzyme II 

Gene Name

 PTDSS2 

Gene Synonyms/Alias

 PSS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
160	FLKYVDPKLGVPLPE	ubiquitination	[1, 2]
271	TLEWLSLKTYKWQGL	ubiquitination	[1, 2, 3]
274	WLSLKTYKWQGLWNI	ubiquitination	[1, 2]
285	LWNIPTYKGKMKRIA	ubiquitination	[1, 2]
447	YKETRWQKWQNKDDQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. 

Sequence Annotation

 MOD_RES 16 16 Phosphoserine.
 MOD_RES 485 485 Phosphothreonine.
 CARBOHYD 181 181 N-linked (GlcNAc...).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 487 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003882; F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IEA:Compara.
 GO:0006659; P:phosphatidylserine biosynthetic process; TAS:Reactome. 

Interpro

 IPR004277; PSS. 

Pfam

 PF03034; PSS 

SMART

  

PROSITE

  

PRINTS