UniProt Accession

 E7EP60_HUMAN; E7EP60 

Genbank Protein ID

 AC020595 

Genbank Nucleotide ID

  

Protein Name

 Integrin alpha-4 

Protein Synonyms/Alias

  

Gene Name

 ITGA4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
95	IYRCRIGKNPGQTCE	ubiquitination	[1, 2, 3]
116	PNGEPCGKTCLEERD	ubiquitination	[1, 2]
149	VTCGHRWKNIFYIKN	ubiquitination	[2]
155	WKNIFYIKNENKLPT	ubiquitination	[2]
159	FYIKNENKLPTGGCY	ubiquitination	[2]
189	PCYQDYVKKFGENFA	ubiquitination	[1, 2, 3]
190	CYQDYVKKFGENFAS	ubiquitination	[2]
236	NITTNKYKAFLDKQN	ubiquitination	[2]
241	KYKAFLDKQNQVKFG	ubiquitination	[2, 3]
280	PQHEQIGKAYIFSID	ubiquitination	[2]
289	YIFSIDEKELNILHE	ubiquitination	[2]
298	LNILHEMKGKKLGSY	ubiquitination	[2]
300	ILHEMKGKKLGSYFG	ubiquitination	[2]
363	TNLVGSDKYAARFGE	ubiquitination	[2]
590	LGPHVISKRSTEEFP	ubiquitination	[2]
606	LQPILQQKKEKDIMK	ubiquitination	[1]
607	QPILQQKKEKDIMKK	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Cell adhesion; Complete proteome; Integrin; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 614 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0060710; P:chorio-allantoic fusion; IEA:Compara.
 GO:0060324; P:face development; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara. 

Interpro

 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2. 

Pfam

 PF08441; Integrin_alpha2 

SMART

 SM00191; Int_alpha 

PROSITE

 PS51470; FG_GAP 

PRINTS

 PR01185; INTEGRINA.