UniProt Accession

 DHPR_RAT; P11348 

Genbank Protein ID

 J03481; BC072536 

Genbank Nucleotide ID

 AAA41099.1; AAH72536.1 

Protein Name

 Dihydropteridine reductase 

Protein Synonyms/Alias

 HDHPR; Quinoid dihydropteridine reductase 

Gene Name

 Qdpr 

Gene Synonyms/Alias

 Dhpr 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
70	QVTAEVGKLLGDQKV	acetylation	[1]
121	ISSHLATKHLKEGGL	acetylation	[1]
124	HLATKHLKEGGLLTL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. 

Sequence Annotation

 NP_BIND 11 35 NADP.
 ACT_SITE 147 147 Proton acceptor.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome; Tetrahydrobiopterin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0004155; F:6,7-dihydropteridine reductase activity; IMP:UniProtKB.
 GO:0070404; F:NADH binding; IPI:RGD.
 GO:0070402; F:NADPH binding; IMP:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0035690; P:cellular response to drug; IEP:RGD.
 GO:0006559; P:L-phenylalanine catabolic process; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0010044; P:response to aluminum ion; IEP:RGD.
 GO:0033762; P:response to glucagon stimulus; IEP:RGD.
 GO:0010288; P:response to lead ion; IEP:RGD.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IMP:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS