| Tag | Content |
|---|
| CPLM ID | CPLM-007727 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arabinose 5-phosphate isomerase KdsD |
Protein Synonyms/Alias | API; L-API |
Gene Name | kdsD |
Gene Synonyms/Alias | yrbH; b3197; JW3164 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | CEKMFWCKGKVVVMG | acetylation | [1] | | 220 | GDEIPHVKKTASLRD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in the KDO biosynthesis and can be substituted by GutQ. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5- phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). |
Sequence Annotation | DOMAIN 42 184 SIS.
DOMAIN 210 268 CBS 1.
DOMAIN 277 328 CBS 2.
REGION 75 76 Substrate binding (By similarity).
REGION 114 123 Substrate binding (By similarity).
REGION 148 150 Substrate binding (By similarity).
METAL 82 82 Zinc (By similarity).
BINDING 82 82 Substrate (By similarity).
BINDING 88 88 Substrate (By similarity).
BINDING 222 222 Substrate (By similarity).
BINDING 275 275 Substrate (By similarity). |
Keyword | 3D-structure; Carbohydrate metabolism; CBS domain; Complete proteome; Isomerase; Lipopolysaccharide biosynthesis; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 328 AA |
Protein Sequence | MSHVELQPGF DFQQAGKEVL AIERECLAEL DQYINQNFTL ACEKMFWCKG KVVVMGMGKS 60
GHIGRKMAAT FASTGTPSFF VHPGEAAHGD LGMVTPQDVV IAISNSGESS EITALIPVLK 120
RLHVPLICIT GRPESSMARA ADVHLCVKVA KEACPLGLAP TSSTTATLVM GDALAVALLK 180
ARGFTAEDFA LSHPGGALGR KLLLRVNDIM HTGDEIPHVK KTASLRDALL EVTRKNLGMT 240
VICDDNMMIE GIFTDGDLRR VFDMGVDVRQ LSIADVMTPG GIRVRPGILA VEALNLMQSR 300
HITSVMVADG DHLLGVLHMH DLLRAGVV 328 |
Gene Ontology | GO:0019146; F:arabinose-5-phosphate isomerase activity; IDA:EcoCyc. GO:0030246; F:carbohydrate binding; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019294; P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IDA:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |